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The CLIMIDSON Manual for Antimicrobial Stewardship Programmes in Nigerian Health Care Facilities

*1Iregbu, K. C., 2Oduyebo, O. O., 3Taiwo, S. S., 1Nwajiobi-Princewill, P. I., 2Oshun, P. O., 4Nwafia, I. N., 5Elikwu, C. J., 6Manga, M. M., 7Oboro, I. L., and 8Kudayah, I. O.

1Department of Medical Microbiology, National Hospital, Abuja, Nigeria

2Department of Medical Microbiology, Lagos University Teaching Hospital, Lagos, Nigeria

3Department of Medical Microbiology, LAUTECH Teaching Hospital, Ogbomoso, Nigeria

4Department of Medical Microbiology, University of Nigeria Teaching Hospital, Enugu, Nigeria

5Department of Medical Microbiology, Babcock University Teaching Hospital, Ilishan-Remo, Nigeria

6Department of Medical Microbiology, Gombe State University Teaching Hospital, Gombe, Nigeria

7Department of Medical Microbiology, Rivers State University Teaching Hospital, Port Harcourt, Nigeria

8Lifeline Children Hospital, Lagos, Nigeria

*Correspondence to: keniregbu@yahoo.co.uk

Executive Summary:

Antimicrobial stewardship (AMS) remains a cornerstone of efforts aimed at improving antimicrobial-related patient safety. It slows the development and spread of antimicrobial resistance (AMR), while helping clinicians to improve clinical outcomes and minimise harm by improving antimicrobial prescribing. AMS programmes (ASPs) are driven through various processes and people. An AMS structure comprises the core elements that should be in place to support the ASP including the AMS team, treatment guidelines, and surveillance of AMR and antimicrobial use (AMU). Continue reading “The CLIMIDSON Manual for Antimicrobial Stewardship Programmes in Nigerian Health Care Facilities”

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Genital mycoplasmas and gynaecologic cancer: A systematic review

*1Ezeanya-Bakpa, C. C., 2Agbakoba, N. R., 2Udeogu, C. V., 2Uduchi, I. O., 3Oguejiofor, C. B., and 2Ekelozie, I. S.

 

1Department of Microbiology and Biotechnology, Caleb University, Lagos, Nigeria

2Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria

3Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Awka, Nigeria

*Correspondence to: cc.ezeanya@gmail.com; chinyere.bakpa@calebuniversity.edu.ng; +234 8068917612;     ORCID: //orcid.org/0000–0002–7844–7414  Abstract:  

Studies on genital mycoplasmas (GM) role in gynaecologic cancers (GC) such as cervical, endometrial, ovarian, vaginal, vulva and fallopian tube, is limited. This review was conducted to evaluate an association between GM and GC. The systematic study was conducted in accordance with PRISMA guidelines across online databases including Embase, Google Scholar, PubMed, Scopus, and Web of Science from inception to August, 2022. Continue reading “Genital mycoplasmas and gynaecologic cancer: A systematic review”

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Microbial menace to kidney health: A review of the role of infections in acute kidney injury

Medugu, N., and *Adegboro, B.

Department of Medical Microbiology and Immunology, Nile University of Nigeria, Abuja, Nigeria

*Correspondence to: boazadegboro@gmail.com; boaz.adegboro@nileuniversity.edu.ng; +234 80 33812348

Abstract:

Acute kidney injury (AKI) of infectious aetiology is a complex condition that requires a comprehensive microbiological evaluation. This includes sepsis workup, evaluation of urinary tract infection (UTI), assessment for viral, fungal, and bacterial infections, consideration of the patient’s microbiome, and vigilance towards antibiotic toxicity. Advanced molecular diagnostic tools such as metagenomic sequencing and rapid point-of-caretesting, may offer future advances in accurate and timely identification of infectious aetiologies in AKI. Continue reading “Microbial menace to kidney health: A review of the role of infections in acute kidney injury”

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Post-exposure prophylaxis for HIV: A 10-year review of data from a tertiary health facility in northcentral Nigeria

*[1]Audu, E. S., [2]Bello, S. O., [3]Ablaku, A., [4]Audu, A. A., 5Bako, I. A., 5Mathew, M., and 6Anazodo, M. C.

1Department of Medical Microbiology, Dalhatu Araf Specialist Hospital, Lafia, Nasarawa State, Nigeria

2Department of Paediatrics, Dalhatu Araf Specialist Hospital, Lafia, Nasarawa State, Nigeria

3Pharmacy Unit, Special Treatment Clinic, Dalhatu Araf Specialist Hospital, Lafia, Nasarawa State, Nigeria

4Department of Human Anatomy, Federal University, Lafia, Nasarawa State, Nigeria

5Department of Community Medicine, Federal University, Lafia, Nasarawa State, Nigeria

6Department of Community Medicine, Dalhatu Araf Specialist Hospital, Lafia, Nasarawa State, Nigeria *Correspondence to: estanamo@gmail.com; +2347083599740 ORCID: 0000-0002-3129-7754

Abstract:  

Background: Post-exposure prophylaxis (PEP) for human immunodeficiency virus (HIV) is the use of short-term antiretroviral therapy (ART) following a single risk exposure to a potential source of HIV infection. If commenced within 72 hours following exposure, PEP has been reported to be very effective in preventing replication and spread of the virus and therefore prevent acquisition of infection. PEP is recommended for exposures occurring in both occupational and non-occupational settings. The objectives of this study are to review the profile of patients and determine the reasons for accessing PEP services in our facility with a view to recommending evidence-based solutions and ultimately contributing to achieving zero transmission of HIV.   Continue reading “Post-exposure prophylaxis for HIV: A 10-year review of data from a tertiary health facility in northcentral Nigeria”

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Prevalence of asymptomatic significant bacteriuria and antibiotic susceptibility pattern of bacterial isolates in HIV-infected patients in Ilorin, Nigeria

*1Bale, M. I., 1Sinumvayo, J. P., 2Badmus, R. A., 3Babatunde, S. K., 4Aroyehun, A. B., and 1Adeyemo, R. O.

  1Department of Microbiology and Parasitology, College of Medicine and Health Sciences,  University of Rwanda, Republic of Rwanda

2Department of Microbiology Faculty of Pure and Applied Sciences, Kwara State University,  Malete, Kwara State, Nigeria

3Department of Biological Sciences, Kola Daisi University, Ibadan, Nigeria

4Department of Clinical Nutrition, University of Aberdeen, King’s College, Aberdeen, AB24 3FX, Scotland

*Correspondence to: muribaale@gmail.com; i.muritala@ur.ac.rw

Abstract:

 Background: Urinary tract infection (UTI) is one of the most common type of infections worldwide, and this is usually preceded by asymptomatic significant bacteriuria (ASB). The emergence of antibiotic resistance in bacteria responsible for UTI makes this entity of public challenge, which has been fueled by human immunodeficiency virus (HIV) infection. This study determined the prevalence of ASB and antimicrobial susceptibility pattern of bacteria isolated from urine samples of selected HIV-infected patients in Ilorin, Nigeria. Continue reading “Prevalence of asymptomatic significant bacteriuria and antibiotic susceptibility pattern of bacterial isolates in HIV-infected patients in Ilorin, Nigeria”

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Automated blood culture systems for isolation of bacterial pathogens of bloodstream infection: The experience of Bobo-Dioulasso Teaching Hospital, Burkina Faso

1Nagalo, A., 1Kaboré, O. D., 1Koulbou, M., 2Sanogo, B., 3Yehouenou, C. L., 5Traoré, I., 4Zoungrana, J., 4Poda, A., and 1Ouédraogo, A-S.

 1Department of Bacteriology Laboratory, Sourô Sanou University Hospital, 01 BP 676, Bobo-Dioulasso, Burkina Faso

2Department of Medical Paediatrics, Sourô Sanou University Hospital, 01 BP 676, Bobo-Dioulasso, Burkina Faso

3Mycobacteria Reference Laboratory (LRM), BP 817, Cotonou, and Faculty of Health Sciences, University of Abomey Calavi, Cotonou, Bénin

4Department of Infectious Diseases, Sourô Sanou University Hospital, 01 BP 676, Bobo-Dioulasso, Burkina Faso

5Department of Intensive Cares, Sourô Sanou University Hospital, 01 BP 676, Bobo-Dioulasso, Burkina Faso

*Correspondence to: nagaloandre@gmail.com; +226 71407137

 

Abstract:

Background: Identification of the causative agent is an essential requirement for better treatment of bloodstream infection. The BacT/Alert 3D (BioMérieux, Marcy l’Étoile, France), is a blood culture system equipped with CO2 sensors to monitor the growth of microorganisms in blood culture bottles designed to optimize bacterial growth. The aim of this study was to determine the performance of this equipment in detecting bacterial pathogens from patients with bloodstream infection in the context of low-and-middle-income countries (LMICs), with Bobo-Dioulasso Teaching Hospital as a case study. Continue reading “Automated blood culture systems for isolation of bacterial pathogens of bloodstream infection: The experience of Bobo-Dioulasso Teaching Hospital, Burkina Faso”

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COVID-19 and Dengue co-infection in paediatric patients: An endemic in a pandemic

†Pavani, S., †Srinath, M., Sultana, W., Rani, V. S., *Mehreen, S. F., and Ravi, V.

Viral Research and Diagnostic Laboratory, Department of Microbiology, Osmania Medical College, Koti, Hyderabad-500095, Telangana, India

*Correspondence to: drfakihamehreen@gmail.com; +91 8500499786

†Authors have equal contribution to the study

 

Abstract:

Background: The clinical presentation and outcome of COVID-19 are likely to be complicated by co-infection with other endemic viruses such as Dengue. This study aimed to investigate the occurrence of co-infections of SARS-CoV-2 and Dengue viruses in paediatric patients from Osmania General Hospital, Hyderabad, Telangana, during the COVID-19 pandemic. Continue reading “COVID-19 and Dengue co-infection in paediatric patients: An endemic in a pandemic”

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In vitro antimicrobial activity of Mathesia® on bacterial isolates of wound infections in University Clinics and Hospital Centre of Mont Amba, Kinshasa, Democratic Republic of the Congo

[1]Nkasa, H. L., [2]Kabena, O., *2Ngbolua, J. K., 3Matafwari, Z.  L., 3Ndamba, P. M.,  4,5Lunguya, O. M., 6Ambimani, C. I., 1Mifundu, M., 1Mulenga, M. C.,         1Malongwe, K. J., 1Kayembe, S. J., and 1Taba, K. M.

1Department of Chemistry, Faculty of Science, University of Kinshasa, Democratic Republic of the Congo

2Department of Biology, Faculty of Science, University of Kinshasa, Democratic Republic of the Congo

3Higher Institute of Medical Technology of Kinshasa, P. O. Box 774 Kinshasa XI Section: Laboratory Technical, Democratic Republic of the Congo

4Department of Medical Biology, Faculty of Medicine, University of Kinshasa, Democratic Republic of the Congo

5National Institute of Biomedical Research, Kinshasa, Democratic Republic of the Congo

6Higher Pedagogical Institute of Isiro, Democratic Republic of the Congo                                            *Correspondence to: jpngbolua@unikin.ac.cd

Abstract:

Background: Mathesia is a hydro-alcoholic emulsion, colourless and somewhat viscous, based on extracts of medicinal plants and containing saponins, polyphenols, tannins, and reducing sugars. In this study, we proposed to carry out an in vitro study of the antibacterial activity of phytomedicine Mathesia on strains of bacteria isolated from diabetic foot ulcers and chronic wounds of patients in care in the University Clinics and the Hospital Centre of Mont Amba in Kinshasa, Democratic Republic of the Congo. Continue reading “In vitro antimicrobial activity of Mathesia® on bacterial isolates of wound infections in University Clinics and Hospital Centre of Mont Amba, Kinshasa, Democratic Republic of the Congo”

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Prevalence and phenotypic characteristics of Acinetobacter baumannii isolated from critically ill patients in two healthcare facilities in Ebonyi State, Nigeria

[1]Ogbonna, O., *1Onuoha, S. C., [2]David, I. E., [3]Onwa, C. N., 4Eromonsele, B. O., and 3Ogbu, O.

1Department of Biotechnology, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria

2Department of Home Economics and Hospitality, Ebonyi State University, Abakaliki, Nigeria         

3Department of Applied Microbiology, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria

4Department of Microbiology, College of Sciences, Evangel University, Akaeze, Ebonyi State, Nigeria

*Correspondence to: sconuoha@yahoo.com

 

Abstract:

 Background: The intrinsic property of Acinetobacter baumannii to survive in harsh conditions on environmental surfaces and its ability to resist commonly used antibiotics in hospitals make this pathogen to be one of the most prevalent causes of hospital infections. The present study was aimed at determining the prevalence of A. baumannii among critically ill patients in two tertiary hospitals; Alex Ekwueme-Federal University Teaching Hospital, Abakaliki (AE-FUTHA) and Mater Misericodiae Hospital Afikpo (MMHA) in Ebonyi State, southeast Nigeria. Continue reading “Prevalence and phenotypic characteristics of Acinetobacter baumannii isolated from critically ill patients in two healthcare facilities in Ebonyi State, Nigeria”

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Bioactive components of Syzygium aromaticum bud and their effects on selected pathogenic bacteria

*[1]Mohammed, A., 1Ahssana, H. J., 1Balogu, T. V., 1Mohammed, I. L., [2]Badeggi U., M., and [3]Suleiman Mohammed.  

1Department of Microbiology, Faculty of Natural Science, Ibrahim Badamasi Babangida University, Lapai, Niger State, Nigeria

2Department of Chemistry, Faculty of Natural Science, Ibrahim Badamasi Babangida University, Lapai, Niger State, Nigeria

3Faculty of Science, Gombe State University, Gombe, Nigeria

*Correspondence to; ibrahimnusaiba2@gmail.com; abdmohammed@ibbu.edu.ng

Abstract:  

Background: The decline in the effectiveness of common antibiotics is due to microbial resistance and has sparked research interest in discovering new antimicrobial agents from plants. The objective of this study was to evaluate the effectiveness of clove extracts on selected pathogenic bacteria and identify the active antibacterial components. Continue reading “Bioactive components of Syzygium aromaticum bud and their effects on selected pathogenic bacteria”