Volume 24.2 – Page 2

^[1]^*Kafando, H., ¹Ouattara, M., ¹Kienou, M., ¹Coulidiaty, Y. D., ¹Ouattara, K., ¹Ouédraogo, R., ¹Sawadogo, M., ¹Guira, C., ^3,4Ouédraogo, A. S., ^[2]^,5Sanou, I., and ^1,2Sangaré, L.

¹Department of Bacteriology and Virology, Yalgado Ouedraogo University Hospital, 03 BP 7022, Ouagadougou 03, Burkina Faso

²Training and Research Unit in Health Science, Joseph KI-ZERBO University, Ouagadougou, Burkina Faso

³National Reference Laboratory for the Control of Antimicrobial Resistance (NRL-AMR), Bobo Dioulasso, Burkina Faso

⁴National Institute of Health Sciences, NAZI BONI University, Bobo Dioulasso, Burkina Faso

⁵Laboratory Department, Tengandogo University Hospital, Ouagadougou, Burkina Faso ^*Correspondence to: hervekafando7@gmail.com; 0022676146695

Abstract:

Background: Escherichia coli is the main bacterium responsible for uncomplicated urinary tract infections (UTI). The increasing frequency of antibiotic resistance in E. coli isolates from UTI poses concern in their therapeutic management. The aim of this study is to describe the current antibiotic resistance profile of E. coli clinical isolates at the Yalgado Ouedraogo University Hospital of Ouagadougou (CHUYO), Burkina Faso, with a view to revising the treatment protocols for bacterial UTI. Continue reading “Antibiotic susceptibility of uropathogenic Escherichia coli isolates in a hospital setting in Ouagadougou, Burkina Faso: A twelve-year retrospective analysis”

^1,2*^†Fatunla, O. A. T., ^3,4^†Irek, E. O., ^1,2Oyebanji, A. H., ²Adisa, S. O., ^[1]Jesulana, T. E., and ²Ajibola, T. O.

¹Department of Paediatrics, Faculty of Clinical Sciences, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria

²Department of Paediatrics, Afe Babalola Multi-System Hospital, Ado-Ekiti, Nigeria

³Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical Sciences, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria

⁴Department of Medical Microbiology and Parasitology, Afe Babalola Multi-System Hospital, Ado-Ekiti, Nigeria

⁵Department of Internal Medicine, Afe Babalola Multi-System Hospital, Ado-Ekiti, Nigeria

*Correspondence to: odunayofatunla@abuad.edu.ng; +2348034397539; ORCiD: //orcid.org/0000 –0002 –2839 –1491

^†Contributed equally to the study

Abstract:

Malaria treatment failure is the inability to clear parasitaemia after antimalarial drug administration. There are reports of treatment failure with artemisinin-based combination therapy (ACT) in Nigeria but few reported among children. We report three paediatric cases of treatment failure with ACT admitted at a private tertiary hospital in Nigeria in early 2022. All three were ‘under-fives’ admitted for open-heart surgery, major flame burns, and cerebral malaria respectively. They had symptomatic Plasmodium falciparum infection but one had mixed P. falciparum and Plasmodium vivax infections. Cases 1 and 2 were initially given oral artemether-lumefantrine while case 3 received intravenous artesunate. Despite appropriate antimalarial drug compliance, all the 3 still had fever with heavy parasitaemia. They subsequently received intravenous quinine, with improvement within the first 24 hours of therapy, and no longer had fever at the fourth week of follow-up. Although ACT resistance was not established, poor drug quality may have contributed to treatment failure. There is a need for pharmacovigilance of anti-malarial in Nigeria. Continue reading “Malaria treatment failure after Artemisinin-based combination therapy: A case series of children managed at a private tertiary hospital in southwest Nigeria”