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Prevalence of high-risk HPV types 16 and 18 in relation to immune status and cervical cytological profile of HIV-infected women on antiretroviral therapy in northcentral Nigeria

1Ajang, A. Y., 1Ella, E. E., 1Oguntayo, A. O., 2Innocent, E., and 1Aminu, M.

1Department of Microbiology, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Nigeria
1Department of Oncology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria
2Department of Histopathology, Jos University Teaching Hospital, Jos, Nigeria
*Correspondence to: yakubuabubakar92@yahoo.com

Abstract:
Background: Human papillomavirus (HPV) is a well-established causal agent of cervical cancer, and the first group of viruses to have been acknowledged to prompt carcinogenesis. They are linked with cancers of the uterine cervix, anogenital tumours, and head and neck malignancies. Cervical cancer is by far the most common HPV-related disease, with about 99% of cervical cancer cases caused by persistent genital high-risk (HR) HPVs, especially types 16 and 18. Continue reading “Prevalence of high-risk HPV types 16 and 18 in relation to immune status and cervical cytological profile of HIV-infected women on antiretroviral therapy in northcentral Nigeria”

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Phenotypic detection of extended-spectrum β-lactamase Enterobacterales isolated from people living with HIV/AIDS in Kinshasa, Democratic Republic of the Congo

1Mbusa Vihembo, G., 1Mbundu Lukukula, C., 1Ngeleka Ngoie J., 2Indeko Lomboto, J., 2Mpoyo Munanga, L., 3Nzingula Phasi, O., 4Bayebila Menanzambi, T., 5Denis, O., 1TakaisiKikuni, N. B., 1Liesse Iyamba, J. M., and *1Mulwahali Wambale, J.

1University Reference Center of Antimicrobial Resistance Surveillance (URC-AMRS), Faculty of Pharmaceutical Sciences, University of Kinshasa, Kinshasa, Democratic Republic of Congo

2BOYAMBI Hospital Centre Laboratory, Barumbu, Kinshasa, Democratic Republic of Congo

3Biochemistry Laboratory, Faculty of Pharmaceutical Sciences, University of Kinshasa, Kinshasa, Democratic Republic of Congo

4Faculty of Pharmaceutical Sciences, University of Kinshasa, Kinshasa, Democratic Republic of Congo

5National Reference Center for Antimicrobial Resistance in Gram-negative bacilli, CHU UCL NAMUR-Yvoir, Belgium

*Correspondence to: jose.mulwahali@unikin.ac.cd

Abstract:
Background: People living with HIV/AIDS (PLWHA) are prone to opportunistic bacterial infections caused by multidrug-resistant organisms. The aim of this study was to determine the susceptibility of Enterobacterales isolated from urine and stool samples of PLWA attending the BOYAMBI Hospital Center, Kinshasa, Democratic Republic of the Congo to commonly used antibiotics and to detect extended-spectrum β-lactamases (ESBLs) producers among the isolates. Continue reading “Phenotypic detection of extended-spectrum β-lactamase Enterobacterales isolated from people living with HIV/AIDS in Kinshasa, Democratic Republic of the Congo”

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Vaginal carriage of Streptococcus agalactiae among pregnant women in Ouagadougou, Burkina Faso

*1Ky/Ba, A., 1Ouattara, A., 2Issa, T., 3Ky, A. Y., 1Ki, C., 2Sanou, M., and 4Sanou, I.

1Bogodogo University Teaching Hospital, Ouagadougou, Burkina Faso

2Charles De Gaulle Paediatric University Teaching Hospital, Ouagadougou, Burkina Faso

3World Vision International/ Burkina Office, Ouagadougou, Burkina Faso

4Tingandogo University Teaching Hospital, Ouagadougou, Burkina Faso

*Correspondence to: absetou@yahoo.fr; +22670120520

Abstract:
Background: Group B Streptococcus (GBS) is one of the main bacteria responsible of serious neonatal infections. Neonatal transmission is very high at the end of pregnancy between the 34th and 38th week of gestation, and the systematic screening of GBS is strongly recommended in Burkina Faso. The objective of this study was to assess the prevalence of GBS carriage among pregnant women in Ouagadougou, Burkina Faso. Continue reading “Vaginal carriage of Streptococcus agalactiae among pregnant women in Ouagadougou, Burkina Faso”

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Bacteraemia at the tertiary care University Hospital Yalgado Ouedraogo: Bacterial species and their antibiotic resistance profiles

*1,2Kafando, H., 3,4Diallo, I., 5Sanou, G., 6Lompo, P., 1Ouédraogo, G. S., 4,7Sanou, I., 4,8Koeta, F., and 2,9Ouédraogo, A. S.

1Laboratory of Bacteriology-Virology, University Hospital Yalgado Ouedraogo, 03 BP 7022, Ouagadougou, Burkina Faso

2National Reference Laboratory for Antimicrobial Resistance Control (NRL-AMR), Bobo Dioulasso, Burkina Faso

3Department of Infectious Diseases, University Hospital Yalgado Ouedraogo, Ouagadougou, Burkina Faso

4Training and Research Unit in Health Science, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso

5Departement of Nephrology-Haemodialysis, University Hospital Yalgado Ouedraogo, Ouagadougou,
Burkina Faso

6Institut de Recherche en Sciences de la Sante, Clinical Research Unit of Nanoro (IRSS-URCN), Nanoro, Burkina Faso

7Department of Laboratory, University Hospital of Tengandogo, Ouagadougou, Burkina Faso

8Department of Paediatrics, University Hospital Yalgado Ouedraogo, Ouagadougou, Burkina Faso

9National Institute of Health Sciences, University Nazi Boni, Bobo Dioulasso, Burkina Faso

*Correspondence to: hervekafando7@gmail.com; +22676146695

Abstract:
Background: Bloodstream infections are serious health problem because of the significant morbidity and mortality they cause. The number of deaths increases in the presence of multidrug resistant bacteria. The aim of this study was to determine the bacteriological and resistance profiles of bacteria isolated from blood cultures. Continue reading “Bacteraemia at the tertiary care University Hospital Yalgado Ouedraogo: Bacterial species and their antibiotic resistance profiles”

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Antibiotic resistance in uropathogenic Escherichia coli strains at Brazzaville University Hospital, Congo and the therapeutic consequences

1,2Mieret, T., 1,3Ontsira Ngoyi, E. N., 1,4Aloumba, A., 1, 4Ossibi Ibara, B. R., and 1,5Odzebe, A. W. S.

1Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congo

2National Public Health Laboratory, Brazzaville, Congo

3Bacteriology-Virology Laboratory, Brazzaville University Hospital, Congo

4Department of Infectious Diseases, Brazzaville University Hospital, Congo

5Department of Urology, Brazzaville University Hospital, Congo

*Correspondence to: tmieret@gmail.com; Tel: 00242068806913

Abstract:
Background: Urinary tract infections (UTIs) are a very frequent reason for consultations and antibiotic prescriptions in everyday practice. Excessive and inappropriate use of antibiotics is responsible for the emergence and spread of multidrug-resistant (MDR) uropathogenic bacteria. The aim of this study was to determine the frequency of isolation and antibiotic resistance of uropathogenic strains of Escherichia coli (UPEC) isolated in the bacteriology-virology laboratory of the University Hospital Centre (CHU) in Brazzaville, Congo. Continue reading “Antibiotic resistance in uropathogenic Escherichia coli strains at Brazzaville University Hospital, Congo and the therapeutic consequences”

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Bacteriological profiles of urinary tract infections in patients admitted to the nephrology-haemodialysis department of the Bogodogo University Teaching Hospital (CHU B), Ouagadougou, Burkina Faso

*1Ky/Ba, A., 2Tondé, I., 1Dienderé, E. A., 3Ky, A. Y., 1Tamini, J. R., 2Sanou, M., and 4Sanou, I

1Bogodogo University Teaching Hospital, Ouagadougou, Burkina Faso

2Charles De Gaulle Pediatric University Teaching Hospital, Ouagadougou, Burkina Faso

3World Vision International/Burkina Office, Ouagadougou, Burkina Faso

4Tengadogo University Teaching Hospital, Ouagadougou, Burkina Faso

*Correspondence to: absetou@yahoo.fr; Tel: +22670120520

Abstract:
Background: Urinary tract infections (UTI) constitute a major public health problem, especially in developing countries such as Burkina Faso. They are commonly encountered in hospitals, particularly in patients suffering from chronic kidney disease whose management requires special measures to avoid treatment failures which are frequent. The objective of this study is to determine the microbial profiles of urinary tract infections (UTIs) in these patients. Continue reading “Bacteriological profiles of urinary tract infections in patients admitted to the nephrology-haemodialysis department of the Bogodogo University Teaching Hospital (CHU B), Ouagadougou, Burkina Faso”

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Phenotypic and genotypic detection of antimicrobial-resistant bacterial pathogens from patients with infectious keratitis in selected hospitals in Ilorin, Nigeria

*1Oladejo, O. J., 2Oladejo, J. M., 3Aina, A., 4Oladejo, P., 4Odetoyin, B., 2Oluwaloniola, V., and 2Tangkat, T.

1Department of Ophthalmology, LAUTECH Teaching Hospital, Ogbomoso, Nigeria

2Department of Microbiology and Parasitology, University of Ilorin Teaching Hospital, Ilorin, Nigeria

3Deparrment of Ophthalmology, Bowen University Teaching Hospital, Ogbomoso, Nigeria

4Department of Microbiology, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria *Correspondence to: olawalejob4@gmail.com

Abstract:
Background: Infectious keratitis is a major cause of global blindness. Standard management approaches typically involve the collection of corneal cultures and initiation of broad-spectrum antimicrobials. However, conventional microbiological techniques, based on direct visualization or cultures of microorganisms, are limited by poor sensitivity and the prolonged time required to produce actionable results. Molecular methods based on nucleic acid amplification technique aim to circumvent the challenges of culture for hours or days. The objectives of this study are to detect the bacteria agents of infectious keratitis in Ilorin, Nigeria, using phenotypic and molecular methods, and to determine their resistance profiles to selected antimicrobials. Continue reading “Phenotypic and genotypic detection of antimicrobial-resistant bacterial pathogens from patients with infectious keratitis in selected hospitals in Ilorin, Nigeria”

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Prevalence and antimicrobial resistance profiles of faecal Escherichia coli isolates from local chickens in Plateau State, Nigeria

Abstract:
Background: Poultry is a profitable business in Nigeria, with economic benefits to families and communities involved in this type of agriculture. However, infection of poultry birds by Escherichia coli can, in addition to causing mortality, results in reduction of egg production, with depletion of protein (egg and meat) and subsequent reduction in market value, consumer supply, cost of veterinary care, and medicines. The objectives of this study are to determine the prevalence and antimicrobial resistance profiles of faecal E. coli isolates from local chickens (Gallus domesticus) in Plateau State, northcentral Nigeria. Continue reading “Prevalence and antimicrobial resistance profiles of faecal Escherichia coli isolates from local chickens in Plateau State, Nigeria”

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Knowledge, attitude and prevention practice against hospital-acquired infections among healthcare workers in National Hospital Abuja, Federal Capital Territory, Nigeria

*1Ilori, O. R., 2,3Attama, U. C., 4Ilori, O. S., 5Akin-Dosumu, V. T., and 5Anegbe, N. E.

1Department of Community Medicine, Ladoke Akintola University of Technology, Ogbomoso, Nigeria

2National Hospital, Abuja, Federal Capital Territory, Nigeria

3Postgraduate School, Ladoke Akintola University of Technology, Ogbomoso, Nigeria

4Department of Surgery, Ladoke Akintola University of Technology, Ogbomoso, Nigeria

5Department of Community Medicine, LAUTECH Teaching Hospital, Ogbomoso, Nigeria *Correspondence to: orilori@lautech.edu.ng; 07031038682; ORCID: 0000-0002-3791-1022

 

Abstract:
Background: Hospital-acquired infections (HAIs) pose serious challenges to safe and high-quality healthcare delivery. They are associated with prolonged hospital stays, disability, economic burden, and mortality, and are usually consequences of poor infection prevention and control practices. The objective of this study was to assess the level of knowledge, attitude and practice of healthcare workers on infection prevention, and the determining factors at the National Hospital Abuja, Nigeria. Continue reading “Knowledge, attitude and prevention practice against hospital-acquired infections among healthcare workers in National Hospital Abuja, Federal Capital Territory, Nigeria”

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Knowledge of antibiotic resistance and habits of antibiotic use among medical students of University of Nigeria Enugu: a descriptive cross-sectional survey

1Nwafia, I., 2Nwafia, S.,2Ibeh, P, *3Ajunwa, K., 2Obaje, O.,2Ehimiyen, R.,2Nwachukwu, L., 2Promise, G., 2Eze, S., 2Igono, F.,2Okoli, N., and 2 Nwadike, S.

1Department of Medical Microbiology, Faculty of Basic Clinical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla Campus, Enugu State, Nigeria

2Faculty of Clinical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla Campus, Enugu State, Nigeria

3Microbiology Research Laboratory, Alex Ekwueme Federal Teaching Hospital, Abakaliki, Ebonyi State, Nigeria

*Correspondence to: ajunwakelechi@gmail.com; +2348062402014 Abstract:

Background: The adverse effects of antimicrobial resistance (AMR) are manifesting worldwide. A major con- tributing factor to AMR is the inappropriate use of antimicrobials in humans and animals. It is imperative to raise awareness among medical students of the current public health challenges of AMR and make them antibiotic guardians because they are the future medical doctors. This survey was designed to assess the knowledge of AMR and habits of antimicrobial use (AMU) among medical students as a means to guide them in their future practice. Continue reading “Knowledge of antibiotic resistance and habits of antibiotic use among medical students of University of Nigeria Enugu: a descriptive cross-sectional survey”