Klebsiella pneumoniae producing extended spectrum β-lactamase in Regional Military University Hospital of Oran, Algeria: antibiotic resistance, biofilm formation, and detection of blaCTX-M and blaTEM genes

*1Benbrahim, C., 1Barka, M. S., 2Benmahdi, L., 3Zatout, A., and 1Khadir, A.

1Laboratory of Applied Microbiology in Food, Biomedical and Environment (LAMAABE), Department of Biology, Faculty of Nature and Life, Earth and Universal Sciences, Abou Bekr Belkaid University, 13000 Tlemcen, Algeria

2Laboratory of Microbiology, Regional Military University Hospital, Oran, Algeria

3Laboratory of Microbiology and Plant Biology, Department of Biological Sciences, Faculty of Natural Sciences and Life, University of Abdlhamid Ibn Badis, Mostaganem, Algeria

*Correspondence to: chahla.benbrahim@univ-tlemcen.dz

Abstract:
Background: Klebsiella pneumoniae is a bacterial pathogen commonly associated with severe nosocomial and community acquired infections especially through the acquisition of extended spectrum β-lactamases (ESβL) and biofilm formation capacity. The objectives of this study are to determine the prevalence of K. pneumoniae ESβL (KP-ESβL)-producing isolates in the Regional Military University Hospital of Oran (HMRUO) Algeria, characterize their antibiotic resistance profile, genetically detect blaTEM and blaCTX-M genes, and evaluate their biofilm formation capacity. Continue reading “Klebsiella pneumoniae producing extended spectrum β-lactamase in Regional Military University Hospital of Oran, Algeria: antibiotic resistance, biofilm formation, and detection of blaCTX-M and blaTEM genes”