Candida albicans – afrjcem.org

*¹Ekwealor, C. C., ²Nweke, C. J., ¹Anaukwu, C. G., ¹Anakwenze, V. N., ¹Ogbukagu, C. M., and ³Mba, A. N.

¹Department of Applied Microbiology and Brewing, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria

²Department of Basic Clinical Science, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria

³David Umahi Federal University of Health Sciences, Uburu, Ebonyi State, Nigeria

*Correspondence to: c.ekwealor@unizik.edu.ng; +234(0)8035080790; ORCID: 0000-0002-7171-2174

Abstract:

Background: Oral candidiasis is an infection that follows colonization of oral cavity by Candida species mostly Candida albicans. About 90% of HIV-infected persons develop this disease during the course of HIV infection and could serve as early sign of HIV-related immunodeficiency. Treatment involves the use of antifungal drugs. The objectives of this study are to determine the prevalence of oral candidiasis and the susceptibility of isolated Candida species to available antifungal agents among selected HIV-infected patients in a mission hospital, southeast Nigeria. Continue reading “Prevalence and antifungal susceptibility pattern of oral candidiasis among HIV-infected patients in a Mission Hospital, southeast Nigeria”

SH Afraseyabi, A Afkhamzadeh, H Sabori, F Verdi, N Khaksar, B Mosavei, E Kalantar

Abstract

Background: Within the past two decades, Candida species have emerged as major human pathogens and are currently the fourth most common cause of nosocomial infection. Propose of this study was to determine the occurrence of oral Candidiasis among cancer patients at Qods hospitals in Sanandaj.
Materials and Methods: Sixty cancer patients were examined for oral candidiasis. For all patients, the clinical diagnosis had to be confirmed microbiologically by the presence of yeasts and / or hyphae or pseudohyphae on potassium hydroxide–treated smears of oral swabs. Oral samples were obtained and cultured on Sabouraud’s dextrose agar and CHROMagar.
Results: 25 out of the 60 patients (41.7%) were males and 35 (58.3%) were females ranging in age from 15 to 79 years. Gastrointestinal cancer and Breast cancer were the most frequent cancer in the studied group, accounting for 65 % and 18.4 % respectively. The mean weight of the patients was 52.67 Kg (range, 38– 80 Kg). Similarly, the mean of hospital stay was 3.58 days (range; 1-9 days). From these patients, 19 Candida spp were isolated; C. albicans alone outnumbered other species and accounted for 73.68% episodes of trash. For C. albicans isolates, the MIC values ranges from 1 to 9 Z g / ml μg / ml for polyenes and from 0.03 to 16 Z g / ml for the azole antifungals. All the Candida albicans had closely related MFCs values.
Conclusion: In conclusions, the finding of our study strongly suggest that oral candidiasis is a frequent complication among cancer patients, being C. albicans the main etiological agent.

Keywords: Cancer, Oral candidiasis, Candida albicans, Antifungal agents

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Oral Candidiasis amongst cancer patients at Qods Hospital