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Prevalence of high-risk HPV types 16 and 18 in relation to immune status and cervical cytological profile of HIV-infected women on antiretroviral therapy in northcentral Nigeria

1Ajang, A. Y., 1Ella, E. E., 1Oguntayo, A. O., 2Innocent, E., and 1Aminu, M.

1Department of Microbiology, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Nigeria
1Department of Oncology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria
2Department of Histopathology, Jos University Teaching Hospital, Jos, Nigeria
*Correspondence to: yakubuabubakar92@yahoo.com

Abstract:
Background: Human papillomavirus (HPV) is a well-established causal agent of cervical cancer, and the first group of viruses to have been acknowledged to prompt carcinogenesis. They are linked with cancers of the uterine cervix, anogenital tumours, and head and neck malignancies. Cervical cancer is by far the most common HPV-related disease, with about 99% of cervical cancer cases caused by persistent genital high-risk (HR) HPVs, especially types 16 and 18. Continue reading “Prevalence of high-risk HPV types 16 and 18 in relation to immune status and cervical cytological profile of HIV-infected women on antiretroviral therapy in northcentral Nigeria”

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Comparative HPV genotype distribution among women with normal and abnormal cervical cytology in Yaoundé, Cameroon

*1Mbimenyuy, C. M., 1Cho, J. F., 2Mugyia, A. E., 3Ikomey, G. M., 4,5Tebit, D. M., and 6Nota, D. A.

1Department of Microbiology and Parasitology, Faculty of Science, P. O. Box 63, Buea, University of Buea, South West Region, Cameroon

2Department of Virology Centre Pasteur Du Cameroun

3Centre for Studies and Control of Communicable Diseases (CSCCD), FMBS-University of Yaoundé 1, Box 8445, Yaoundé, Cameroon

4HIV/AIDS and Global Health Research Program, and Department of Microbiology, University of Venda, Thohoyandou 0950, South Africa

5Global Biomed Scientific LLC, P.O. Box 2368, Forest, VA 24551, USA

6Department of Biological Sciences, University of Bamenda, North West Region, Cameroon

*Correspondence to: cmbimenyuy@yahoo.com

 

Abstract:

Background: The epidemiology of human papillomavirus (HPV) infection and the pattern of HPV genotype distribution are parameters needed to assess the risk of cervical cancer. Oncogenic HPV types are well-known pathogen for lower genital tract neoplasias, representing the primary cause of cancer death in Africa and the second in Cameroon. This study was conducted to identify the various genotypes particularly the high-risk HPV types in normal and abnormal cervical cytology from women in Yaoundé, Cameroon.

Methodology: This was a hospital-based, analytical cross-sectional study carried out on 226 symptomatic women wherein cervico-vaginal samples were obtained during gynaecological examination for Pap smears, HPV-DNA and genotype detection with linear array HPV strip, conducted from November 2019 to January 2021. Continue reading “Comparative HPV genotype distribution among women with normal and abnormal cervical cytology in Yaoundé, Cameroon”