Prevalence of carbapenemase production in Pseudomonas aeruginosa isolates causing clinical infections in Lagos University Teaching Hospital, Nigeria

1Ettu, A. O., *2Oladapo, B. A., and 2Oduyebo, O., O.
1Department of Medical Microbiology and Parasitology, Lagos University Teaching Hospital, Nigeria
2Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Nigeria

*Correspondence to: [email protected]; 08053505952

Abstract:
Background: Pseudomonas aeruginosa has been highly associated with carbapenem resistance in which carbapenemases has been suggested to be a major contributory factor. Hence the objective of this study was to phenotypically detect KPC-type carbapenemase, metallo-β-lactamase and OXA-48 carbapenemase production in clinical isolates of P. aeruginosa in Lagos University Teaching Hospital (LUTH), Nigeria Continue reading “Prevalence of carbapenemase production in Pseudomonas aeruginosa isolates causing clinical infections in Lagos University Teaching Hospital, Nigeria”

ESβL, AmpC and carbapenemase co-production in multi-drug resistant Gram-negative bacteria from HIV-infected patients in southwestern Nigeria

*Adeyemi, F. M., and Akinde, S. B.
Department of Microbiology, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria *Correspondence to: [email protected]; +234 803 494 0747

Abstract:
Background: The rising global emergence of Gram-negative bacteria (GNB) producing β-lactam hydrolysing enzymes in clinical infections constitutes a growing public health threat. This study investigated the occurrence of co-production of extended spectrum β-lactamase (ESβL), AmpC β-lactamases, and carbapenemases among GNB isolated from HIV-infected patients in two tertiary healthcare facilities in southwest Nigeria. Continue reading “ESβL, AmpC and carbapenemase co-production in multi-drug resistant Gram-negative bacteria from HIV-infected patients in southwestern Nigeria”