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Prevalence, molecular characteristics and antibiotic susceptibility of clinical isolates of Clostridioides difficile in southeastern Nigeria

*1,2Oghonyon, 1,3Ugwu, M. C., 1,3Esimone, C. O., and 2Onah, A. I.

 [1]Department of Pharmaceutical Microbiology and Biotechnology, Nnamdi Azikiwe University Awka, Anambra State, Nigeria

[2]Department of Pharmaceutical Microbiology and Biotechnology, David Umahi Federal University of Health Sciences, Uburu, Ebonyi State, Nigeria

[3]TETFUND Centre of Excellence for Biomedical, Engineering and Agricultural Translational studies, Nnamdi

Azikiwe University Awka, Anambra State, Nigeria

*Correspondence to: oghonyonei@dufuhs.edu.ng, eddisonioghonyon@gmail.com; +2348038469094

 

Abstract:

 Background: Clostridioides difficile is a major contributor to healthcare-associated infections, exhibiting global variations in its prevalence and resistance. There is an absence of data on its molecular characteristics and antibiotic susceptibility of C. difficile in southeastern Nigeria. This study aims to evaluate its prevalence, molecular features, and resistance patterns to enhance treatment and control strategies.  Continue reading “Prevalence, molecular characteristics and antibiotic susceptibility of clinical isolates of Clostridioides difficile in southeastern Nigeria”

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The influence of exposure to various concentrations of five antimicrobial agents on intracellular cytotoxin B production in Clostridioides difficile

1Jamal, W., 2Duerden, B. I., and *3Rotimi, V. O.

1Department of Microbiology, College of Medicine, Kuwait University, Kuwait

2Department of Medical Microbiology, University of Wales, Cardiff, United Kingdom

3Center for Infection Control and Patient Safety, College of Medicine University of Lagos, Nigeria

*Correspondence to: bunmivr@yahoo.com

 

Abstract:

 Background: Clostridioides difficile is an important cause of healthcare-associated diarrhea. Several anti- microbial agents are known to promote C. difficile infection (CDI). The impact of various concentrations of ampicillin (AMP), cefotaxime (CTX), clindamycin (CC), metronidazole (MTZ) and vancomycin (VAN) on intracellular cytotoxin B production was investigated in this study. Continue reading “The influence of exposure to various concentrations of five antimicrobial agents on intracellular cytotoxin B production in Clostridioides difficile”