Akinwande, K. S., and *Arinola, G. O
Department of Immunology, University of Ibadan, Nigeria
*Correspondence to: drarinolaog64@yahoo.com; +234 80 23451520
Abstract:
Background: Intestinal helminth infection is associated with altered immune responses and compromised vaccine efficacy in infected children. Altered immune response due to Ascaris lumbricoides infection may compromise efficacy of oral poliovirus vaccination in children. There is no information on humoral immune response during oral poliovirus (OP) vaccination of A. lumbricoides–infected Nigerian children. The objective of this study is to determine the serum levels of cytokines (tumour necrosis factor–alpha TNF-α, interferongamma IFN–γ, interleukins -4, -6, -8, -10) and poliovirus-specific IgA (PV-IgA) antibody in children infected with A. lumbricoides compared with helminth-negative children (control) before and after oral poliovirus vaccination. Continue reading “Comparative analysis of poliovirus-specific IgA and cytokine levels in the sera of Ascaris lumbricoides-infected and helminth-negative Nigerian children after oral poliovirus vaccination”