[1]Chadha, A., 1,2Jamal, W., and *3Rotimi, V. O.
Departments of Microbiology, 1Mubarak Al Kabeer Hospital, 2Faculty of Medicine, Kuwait University, Health Sciences Center, Jabriya, Kuwait 3Department of Microbiology and Parasitology, Faculty of Basic Clinical Sciences, Lagos State University College of Medicine, Ikeja, Nigeria *Correspondence to: bunmivr@yahoo.com
Abstract:
Background: The emergence and high ascendancy of infections caused by extensively-drug-resistant (XDR) and pandrug-resistant (PDR) Enterobacterales isolates is a serious clinical and public health challenge. Isolation of PDR Gram-negative bacteria (GNB) in clinical setting is very rare and rarer is the infection caused by XDR GNB. Apart from restricted therapeutic options, these infections are associated with increased mortality and morbidity. Urgent studies to re-evaluate existing therapeutic options and research into new antibiotic molecules are desperately needed. The objectives of this study are to report the emergence of rarely encountered multidrug-resistant (MDR), difficult-to-threat, CRE infections in our hospital and investigate their molecular epidemiology.
Methodology: This was a retrospective observational analysis of six patients with severe infections caused by XDR and PDR Enterobacterales isolates at Mubarak AL Kabeer Teaching Hospital, Jabriya, Kuwait, over a period of one and half years. The mechanisms of resistance in these isolates were then prospectively investigated by molecular characterization and genomic studies. Continue reading “Emergence of nosocomial-acquired extensively drug-resistant and pandrug-resistant Enterobacterales in a teaching hospital in Kuwait”