*1Olaniyan, O. A, 2Olowookere, A. K., 3Adelakun, A. A., 4Olaniyi, J. O., 5Zakariyau, T. O., 2Adeniji, T. W., 2Olaniyan, A. M., 2Oguntola, A. M., and 2Taiwo, S. S.
Departments of 1Chemical Pathology, 2Medical Microbiology, and
5Haematology/Blood Transfusion, LAUTECH Teaching Hospital, Ogbomoso, Nigeria
3Department of Medical Laboratory Science, Babcock University, Ilishan-Remo, Ogun State, Nigeria
4TB DOTS Clinic, LAUTECH Teaching Hospital, Ogbomoso, Nigeria *Correspondence to:peace_amazinggrace@yahoo.co.uk
Abstract:
Background: Several anti-tuberculous drugs have been effective in the treatment and management of drug- sensitive and -resistant tuberculosis (TB). While these drug combinations have proven to be highly active against tubercle bacilli, side effects and toxicity may occur with tendency to interrupt or discontinue therapy, resulting in poor compliance. The objective of this study is to assess hepatotoxic potentials of anti-TB drugs among patients with rifampicin-resistant TB (RRTB) undergoing treatment at the directly observed treatment short-course (DOTS) clinic of Ladoke Akintola University of Technology (LAUTECH) Teaching Hospital, Ogbomoso, Nigeria.
Methodology: This was a prospective study of 40 patients with RRTB on second-line anti-TB therapy including bedaquiline, moxifloxacin, prothionamide, ethambutol, pyrazinamide, isoniazid and clofazimine. RRTB was diagnosed by sputum smear AFB microscopy and Xpert MTB/RIF assay at the TB laboratory of Bowen University Teaching Hospital, Ogbomoso, Nigeria. Forty gender and age-matched apparently healthy persons were used as control. Venous samples (~5ml) were collected from each participant at baseline (prior to commencement of anti-TB therapy) and after completion of 9-11 months therapy, as well as from the controls. Plasma was separated by centrifugation and the activity of ALT, AST and ALP was measured by spectrophotometric analysis, while total protein and albumin levels were determined using routine methods. Data were presented as mean±SD and analysed using SPSS version 21.0. Comparison of the mean enzyme activity at baseline and after completion of therapy as well as with the control was done with unpaired ‘t’ test, and ‘p’ (two tail) value less than 0.05 was considered statistically significant. Continue reading “Assessment of selected liver enzyme activity in patients with rifampicin-resistant tuberculosis receiving treatment at a tertiary healthcare facility, southwest Nigeria”