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A point-prevalence survey of carbapenem-resistant Enterobacteriaceae in two different cities in Kuwait and Nigeria 

[1]Jamal, W., [2]Iregbu, K., 1Al Fadhli, A., 1Khodakhast, F., 2Nwajiobi-Princewill, P., 2Medugu, N., and *3Rotimi, V. O.

1Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait

2Department of Clinical Microbiology, National Hospital, Abuja, Nigeria                                                  

3Department of Medical Microbiology, Lagos State University College of Medicine, Ikeja, Nigeria

*Correspondence to: bunmivr@yahoo.com; +234 909 215 0971

Abstract: 

Background: The family Enterobacteriaceae belongs to the order Enterobacterales, a large diverse group of Gramnegative, facultatively anaerobic bacteria that sometimes cause multidrug-resistant infections which treatment options are often challenging. They are the leading cause of nosocomial bloodstream infection (BSI) and urinary tract infections (UTI). The objective of the study was to carry out a point-prevalence survey of antimicrobial resistance and carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates in two hospitals in Kuwait and Nigeria. Continue reading “A point-prevalence survey of carbapenem-resistant Enterobacteriaceae in two different cities in Kuwait and Nigeria “

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Emergence of nosocomial-acquired extensively drug-resistant  and pandrug-resistant Enterobacterales in a teaching hospital in Kuwait

[1]Chadha, A., 1,2Jamal, W., and *3Rotimi, V. O.

Departments of Microbiology, 1Mubarak Al Kabeer Hospital, 2Faculty of Medicine, Kuwait University, Health Sciences Center, Jabriya, Kuwait                      3Department of Microbiology and Parasitology, Faculty of Basic Clinical Sciences, Lagos State University College of Medicine, Ikeja, Nigeria *Correspondence to: bunmivr@yahoo.com

Abstract:

 Background: The emergence and high ascendancy of infections caused by extensively-drug-resistant (XDR) and pandrug-resistant (PDR) Enterobacterales isolates is a serious clinical and public health challenge. Isolation of PDR Gram-negative bacteria (GNB) in clinical setting is very rare and rarer is the infection caused by XDR GNB. Apart from restricted therapeutic options, these infections are associated with increased mortality and morbidity. Urgent studies to re-evaluate existing therapeutic options and research into new antibiotic molecules are desperately needed. The objectives of this study are to report the emergence of rarely encountered multidrug-resistant (MDR), difficult-to-threat, CRE infections in our hospital and investigate their molecular epidemiology.

Methodology: This was a retrospective observational analysis of six patients with severe infections caused by XDR and PDR Enterobacterales isolates at Mubarak AL Kabeer Teaching Hospital, Jabriya, Kuwait, over a period of one and half years. The mechanisms of resistance in these isolates were then prospectively investigated by molecular characterization and genomic studies. Continue reading “Emergence of nosocomial-acquired extensively drug-resistant  and pandrug-resistant Enterobacterales in a teaching hospital in Kuwait”