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A point-prevalence survey of carbapenem-resistant Enterobacteriaceae in two different cities in Kuwait and Nigeria 

[1]Jamal, W., [2]Iregbu, K., 1Al Fadhli, A., 1Khodakhast, F., 2Nwajiobi-Princewill, P., 2Medugu, N., and *3Rotimi, V. O.

1Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait

2Department of Clinical Microbiology, National Hospital, Abuja, Nigeria                                                  

3Department of Medical Microbiology, Lagos State University College of Medicine, Ikeja, Nigeria

*Correspondence to: bunmivr@yahoo.com; +234 909 215 0971

Abstract: 

Background: The family Enterobacteriaceae belongs to the order Enterobacterales, a large diverse group of Gramnegative, facultatively anaerobic bacteria that sometimes cause multidrug-resistant infections which treatment options are often challenging. They are the leading cause of nosocomial bloodstream infection (BSI) and urinary tract infections (UTI). The objective of the study was to carry out a point-prevalence survey of antimicrobial resistance and carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates in two hospitals in Kuwait and Nigeria. Continue reading “A point-prevalence survey of carbapenem-resistant Enterobacteriaceae in two different cities in Kuwait and Nigeria “

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Empirical antibiotherapy as a potential driver of antibiotic resistance: observations from a point prevalence survey of antibiotic consumption and resistance in Gombe, Nigeria

*1Manga, M. M., 1Ibrahim, M., 2Hassan, U. M., 2Joseph, R. H., 2Muhammad, A. S.,  3Danimo, M. A., 4Ganiyu, O., 5Versporten, A., and 6Oduyebo, O. O.

1Department of Medical Microbiology and Immunology, Gombe State University/ Federal Teaching Hospital, Gombe, Nigeria

2Department of Medical Microbiology and Immunology, Federal Teaching Hospital, Gombe, Nigeria                 

3Department of Community Medicine, Gombe State University/Federal Teaching Hospital, Gombe, Nigeria

4Department of Medicine, Gombe State University/Federal Teaching Hospital, Gombe, Nigeria

5Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium

6Department of Medical Microbiology, University of Lagos/Lagos University Teaching Hospital, Lagos, Nigeria

*Correspondence to: drmmanga@gmail.com

Abstract:

Background: Empirical use of antibiotics is a standard practice in the treatment of infections worldwide. However, its over utilization without subsequent culture and antibiotic susceptibility testing could be a major driver of resistance. Over reliance on empirical antibiotherapy is common in most developing countries where antibiotic policies and availability or utilization of clinical microbiology laboratory are suboptimal. A standardized approach to point prevalence survey (PPS) on antimicrobial use (AMU) in hospitals was employed to assess the antimicrobial prescribing practices in Federal Teaching Hospital Gombe (FTHG), Nigeria.

Methodology: A PPS was conducted in April 2019 at FTHG by recruiting all in-patients present in the hospital on the day of survey. Data obtained from patients’ records included details of the type and indication for antibiotherapy. A customized online application developed by the University of Antwerp (www.global–pps.be) was used for data-entry, validation, analysis and reporting.      Continue reading “Empirical antibiotherapy as a potential driver of antibiotic resistance: observations from a point prevalence survey of antibiotic consumption and resistance in Gombe, Nigeria”

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Using longitudinal antibiotic point prevalence survey (PPS) to drive antimicrobial stewardship programmes in a Nigerian tertiary hospital

*1Nwajiobi-Princewill, P., 1Medugu, N., 1Gobel, M., 1Aigbe, A., 2Versporten, A.,  2Pauwels, I., 2Goossens, H., and 1Iregbu, K. C.

 1Department of Medical Microbiology, National Hospital, Abuja, Nigeria 2Laboratory of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium

*Correspondence to: princewill101@yahoo.com

 

Abstract:

Background: Antimicrobial stewardship (AMS) provides a means of tackling antimicrobial resistance (AMR). Unfortunately, in Nigeria, like in some other low-and-middle-income countries (LMICs), AMS practice has been lacklustre due to poor institutional support amongst other factors. Efforts were made to address this situation by engaging with the management of National Hospital Abuja, Nigeria, using antibiotic prescription information obtained through repeated point prevalence survey.  Continue reading “Using longitudinal antibiotic point prevalence survey (PPS) to drive antimicrobial stewardship programmes in a Nigerian tertiary hospital”