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Molecular detection of antimicrobial resistance genes in multidrug-resistant Gram-negative bacteria isolated from clinical samples in two hospitals in Niger

*1Abdoulaye, O., 2Abdoulaye, I., 3Alassane Halawen, M., 4Ibrahim Mamadou, A. K., 1,5Maman Sani Falissou, S., 5,6Adamou Amatagas, S., 1Boureima, H., 2Boubacar Issaka, B., 2Ide, H., 7Yacouba, A., 1,5Sidi Maman Bacha, B., 3Chaibou, S., 2Hamadou, I., 1Harouna Amadou, M. L., 2Ousmane, S., 5Doutchi, M., and 7Mamadou, S.

1Faculté des Sciences de la Santé, Université de Dan Dicko Dankoulodo de Maradi, BP 465, Niger

2Centre de Recherche Médicale et Sanitaire, Niamey, Niger

3Hôpital Général de Référence de Niamey, Niger

4Centre Hospitalier Régional de Dosso, Niger

5Hôpital National de Zinder, Niger

6Faculté des Sciences de la Santé, Université André Salifou de Zinder, Niger

7Faculté des Sciences de la Santé, Université Abdou Moumouni, Niamey, Niger

*Correspondence to: ousmaneabdoulaye2010@yahoo.com; Cel: (+227) 96354580

Abstract:
Background: According to the World Health Organization (WHO), bacterial resistance to antibiotics is a global public health challenge, which is also developing in Niger. The aim of this study was to determine the prevalence of antibiotic resistance genes in Gram-negative bacilli isolated from clinical samples in the biological laboratories of two selected health facilities in Niger. Continue reading “Molecular detection of antimicrobial resistance genes in multidrug-resistant Gram-negative bacteria isolated from clinical samples in two hospitals in Niger”

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Emergence of nosocomial-acquired extensively drug-resistant  and pandrug-resistant Enterobacterales in a teaching hospital in Kuwait

[1]Chadha, A., 1,2Jamal, W., and *3Rotimi, V. O.

Departments of Microbiology, 1Mubarak Al Kabeer Hospital, 2Faculty of Medicine, Kuwait University, Health Sciences Center, Jabriya, Kuwait                      3Department of Microbiology and Parasitology, Faculty of Basic Clinical Sciences, Lagos State University College of Medicine, Ikeja, Nigeria *Correspondence to: bunmivr@yahoo.com

Abstract:

 Background: The emergence and high ascendancy of infections caused by extensively-drug-resistant (XDR) and pandrug-resistant (PDR) Enterobacterales isolates is a serious clinical and public health challenge. Isolation of PDR Gram-negative bacteria (GNB) in clinical setting is very rare and rarer is the infection caused by XDR GNB. Apart from restricted therapeutic options, these infections are associated with increased mortality and morbidity. Urgent studies to re-evaluate existing therapeutic options and research into new antibiotic molecules are desperately needed. The objectives of this study are to report the emergence of rarely encountered multidrug-resistant (MDR), difficult-to-threat, CRE infections in our hospital and investigate their molecular epidemiology.

Methodology: This was a retrospective observational analysis of six patients with severe infections caused by XDR and PDR Enterobacterales isolates at Mubarak AL Kabeer Teaching Hospital, Jabriya, Kuwait, over a period of one and half years. The mechanisms of resistance in these isolates were then prospectively investigated by molecular characterization and genomic studies. Continue reading “Emergence of nosocomial-acquired extensively drug-resistant  and pandrug-resistant Enterobacterales in a teaching hospital in Kuwait”