*1Adegboro, B., 2Abayomi, S. A., 1Imran, J., and 3Sanni, E. O.
1Department of Medical Microbiology and Immunology, Nile University of Nigeria, Abuja, Nigeria
2Department of Medical Microbiology, LAUTECH Teaching Hospital, Ogbomoso, Nigeria
3Department of Haematology, Nile University of Nigeria, Abuja, Nigeria *Correspondence to: boazadegboro@gmail.com
Abstract:
Dexamethasone is a potent synthetic member of the glucocorticoid class of corticosteroid drugs that has been useful for the management of some pathological disorders because it affects a protean number of signaling pathways. It is used as adjunct therapy in the management of sepsis, arthritis, cardiac transplant, blood, hormone/immune system disorders, allergic reaction, skin, eye conditions, cancer and other pathologic disorders and as a mainstay of therapy in autoimmune hepatitis. With the advent of COVID-19, there have been investigations of its use as anti-inflammatory agent in severely ill patients. This present review elucidates the various studies on the use of dexamethasone in the management of severe respiratory tract infections, with the ultimate aim of reducing mortality amongst severely ill patients, including COVID-19. Continue reading “Use of dexamethasone in the management of respiratory tract infections”