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Serological study of leptospirosis in cats from Algeria

*[1]Zaidi, S., [2]Amara Korba, A., [3]Bessas, A., 2Bouzenad A., 2Hamnoune, N. K.,   [4],[5]Hezil, Dj., and 6Bitam, I.

1Higher National Veterinary School, El Alia, Oued Smar, 1615, Algiers, Algeria

2Leptospira unit, Pasteur Institute of Algeria, Rue 1 of Doctor Laveran, Hamma Anassers Algiers, Algeria

3Department of Biology, Faculty of Sciences, University of Algiers 1 (Benyoucef Benkhedda University), Algiers, Algeria

4Research Laboratory Management of Local Animal Resources, Higher National Veterinary School of Algeria, ENSV, Algeria

5 Department of Biology, Faculty of Sciences, M’Hamed Bougara University, Boumerdes, Algeria

6Higher School of Food Sciences and Agri-Food Industries, Algiers, Algeria *Correspondence to: zaidi.ensv@gmail.com; s.zaidi@ensv.dz

 

Abstract:

Background: By the nature of their environment and behavior, stray cats are at risk of exposure to leptospirosis. Leptospirosis is an emerging zoonotic disease with worldwide distribution. The prevalence of leptospirosis in the feline species in Algeria is unknown. The main objectives of this study are to determine the seroprevalence and identify the most common Leptospira serovars in stray cats in the Algiers region. Continue reading “Serological study of leptospirosis in cats from Algeria”

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Sero-prevalence of and risk factors associated with Helicobacter pylori infections among individuals with peptic ulcer in Owerri, Imo State, Nigeria during 2020-2021

*1Okoroiwu, G. I. A., 2Okoroiwu, I. L., 1Ubosi, N. I., and 3Sani, N. M.

 

1Department of Public Health, Faculty of Health Sciences, National Open University of Nigeria, Jabi, Abuja, Nigeria

 2Department of Medical Laboratory Science, Faculty of Health Sciences, Imo State University Owerri, Imo State, Nigeria

3Department of Microbiology, Kano State University of Science and Technology, Wudil, Kano State, Nigeria

*Correspondence to: okoroiwugia@yahoo.com; 08036677539

 

Abstract:

 

Background: Helicobacter pylori, which is a causative agent of chronic gastritis, duodenal ulcer and gastric cancer, presently affects approximately one half of the world population. This study was conducted to assess the epidemiology and risk factors for acquisition of H. pylori among individuals with and without peptic ulcer symptoms in Owerri, Nigeria, in order to provide baseline data and create awareness for effective management and prevention of infection caused by this pathogen. Continue reading “Sero-prevalence of and risk factors associated with Helicobacter pylori infections among individuals with peptic ulcer in Owerri, Imo State, Nigeria during 2020-2021”

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Serological evidence of association between Helicobacter pylori infection and coronary artery disease

1EL-Ageery, S. M., *1,4Gouda, N. S., 2Fawzy, I. M., 3Bahy-Eldeen, A., and 3Mahmoud, R.

1Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Egypt

2Mansoura Central Laboratories, Clinical Pathology Department, Ministry of Health, Egypt

3Internal Medicine Department, Faculty of Medicine, Mansoura University, Egypt

4Medical Microbiology and Immunology Department, Faculty of Medicine, Northern Border University, Kingdom of Saudi Arabia

*Correspondence to: nawalsalama@gmail.com; 00966502933179

Abstract:

Background: Studies have reported relationship between chronic Helicobacter pylori infection and coronary artery disease (CAD). The cytotoxin-associated gene A product (CagA) is an immunodominant protein which indicates infection with virulent H. pylori strains. Significant associations of CagA-positive H. pylori strains with coronary artery disorders have been widely reported. H. pylori is also known to produce different heat shock proteins (HSPs) which can stimulate the production of specific antibody against microbial proteins and capable of eliciting autoimmune reaction against human tissue expressing HSPs such as vascular endothelial cells. The objectives of this study are to investigate the association between H. pylori and CagA with coronary atherosclerosis and CAD, and to determine the possible role of H. pylori HSP60 protein in increasing the risk of CAD development.

Methods: This study included 70 patients with stable angina and 70 age and gender-matched controls. Each group was evaluated by clinical history, physical examination, cardiac echocardiography (ECHO) and electrocardiography (ECG) with and without exercise. Fasting blood glucose, total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides (TG) were estimated by automated enzymatic methods. H. pylori IgG, CagA IgG and HSP60 IgG were measured by enzyme-linked immunosorbent assay (ELISA) for both groups. Continue reading “Serological evidence of association between Helicobacter pylori infection and coronary artery disease”