A review of staphylococcal scalded skin syndrome

1Medugu, N., 1Imran, J., 2Musa-Booth, T. O., 3Makun, B., and *1Adegboro, B.

 1Department of Medical Microbiology and Immunology, Nile University of Nigeria, Abuja, Nigeria

21928 Woodlawn Drive, Woodlawn, Maryland 21207, USA     

3Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria

*Correspondence to: boazadegboro@gmai.com; boaz.adegboro@nileuniversity.edu.ng


Staphylococcal scalded skin syndrome (SSSS) is characterized by widespread epithelial necrosis and/or superficial blistering of the skin following infection by some toxigenic strains of Staphylococcus aureus. The disease primarily affects children under the age of 5 years, but it can also occur in adults. Due to the recent increase in reported cases of SSSS, we have reviewed the epidemiology, pathogenesis, clinical features, diagnosis, treatment, and prevention, including the development of vaccines for S. aureus infections. Electronic databases including PubMed, Google Scholar and websites of the Center for Disease Prevention and Control (CDC), and the World Health Organization (WHO), were searched for publications on SSSS written in English language. Our review showed that SSSS is more common in children, amongst whom it carries a mortality rate of <5%, as opposed to mortality rate of >50% in affected adults. Penicillinase-resistant penicillins are recommended for the treatment of SSSS, and administration of fresh frozen plasma (FFP) may aid early recovery. Important staphylococcal vaccine candidates are also highlighted in the review.

Keywords: staphylococcal scalded skin syndrome, staphylococcal skin infection, staphylococcal vaccines

A review of staphylococcal scalded skin syndrome