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Prevalence and distribution of cervical high-risk human papillomavirus infection in a rural community of Edo State, Nigeria

[1]Okoeguale, J., *[2]Samuel, S. O., [3]Amadi, S. C., 1Njoku, A., and 1Okome, G. B. O.

1Department of Obstetrics and Gynaecology, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria

2Department of Medical Microbiology, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria

3Department of Obstetrics and Gynaecology, Rivers State University Teaching Hospital, Port Harcourt, Nigeria

*Correspondence to: samuelolowo2003@gmail.com

Abstract:

Background: Human papillomaviruses (HPVs) are non-enveloped, double-stranded DNA viruses and most women in the world are probably infected with at least one type of the virus during their sexual life. Oncogenic HPVs are predominantly sexually-transmitted pathogens and several high-risk types are associated with nearly all cases of cervical cancer worldwide. In view of paucity of data on the prevalence and distribution of various high risk HPV subtypes, this study was carried out to provide evidence based local data for cervical cancer preventive programs within this region.

Methodology: This was a descriptive cross-sectional study involving 145 consenting women living in Ugbegun rural community of Edo central senatorial district, Edo State, Nigeria. Informed consent of each participant was obtained and socio-demographic information collected through interviewer-administered collection tool. Cervical swab sample was collected using the female cervical cell collection kit for HPV DNA testing. HPV DNA was detected by the Hybribio 21 HPV Geno array test kit which uses polymerase chain reaction (PCR) amplification and flow through hybridization assay. Summary statistics were presented as mean, standard deviation, median, frequency and proportions as appropriate using the Statistical Package for the Social Sciences (SPSS) version 22.0. Association of sociodemographic characteristics of the women with HPV prevalence was done using the ‘t’ test, with p value less than 0.5 considered statistical significance. Continue reading “Prevalence and distribution of cervical high-risk human papillomavirus infection in a rural community of Edo State, Nigeria”

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Cerebrospinal fluid xanthochromia in acute bacterial meningitis as a red herring for subarachnoid haemorrhage: A case report

*1Adesokan, M. A., and 2Akbari, A. R.

1Emergency Department, University Hospital Ayr, Ayrshire, Scotland, United Kingdom

2King’s Mill Hospital, Sherwood Forest Hospitals NHS Foundation Trust, Nottinghamshire, United Kingdom

*Correspondence to: Adedapo.muideen@nhs.net; dapoadesokan@gmail.com

ORCiD: 0000-0003-3132-945X

 

Abstract:

 This article presents a case that highlights the importance of excluding underlying intracranial pathology in a patient presenting with severe headache and positive xanthochromia. This case report demonstrated that false-positive xanthochromia without subarachnoid haemorrhage (SAH) is possible in acute bacterial meningitis when there is a combination of traumatic lumbar puncture and either hyperbilirubinaemia or raised cerebrospinal fluids (CSF) protein. Continue reading “Cerebrospinal fluid xanthochromia in acute bacterial meningitis as a red herring for subarachnoid haemorrhage: A case report”

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Harness innovation to reduce the malaria disease burden and save lives

1Musa-Booth, T. O., *2Adegboro, B., 3Babazhitsu, M., 2Medugu, N., 4Abayomi, S. A., 5Sanni, O., and 6Ashiru, O.

11928 Woodlawn Drive, Woodlawn, Maryland 21207, USA
2Department of Medical Microbiology and Immunology, Nile University of Nigeria, Abuja, Nigeria
3Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical Sciences, College of Health
Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
4Department of Medical Microbiology, LAUTECHN Teaching Hospital, Ogbomoso, Nigeria
5Department of Haematology, Nile University of Nigeria, Abuja, Nigeria
6Medical ART Center, Lofom House, 21, Mobolaji Bank Anthony Way, Mayland, Lagos, Nigeria
*Correspondence to: boazadegboro@gmail.com; boaz.adegboro@nileuniversity.edu.ng Continue reading “Harness innovation to reduce the malaria disease burden and save lives”