Isolated axillary tuberculous lymphadenitis in a Nigerian female: A case report with review of the literature

*1Uchendu, J. O., 2Yovwin, D. G., and 3Esemuede, O.

 1Department of Histopathology/Morbid Anatomy, Delta State University, Abraka, Nigeria

2Department of Family Medicine, Delta State University Teaching Hospital, Oghara, Nigeria

3Department of Obstetrics and Gynecology, Delta State University Teaching Hospital, Oghara, Nigeria *Correspondence to: ojlinksent@gmail.com; +234 (0) 8038732062

Abstract:

Tuberculosis (TB) is a chronic granulomatous infectious pulmonary and systemic disease caused mostly by members of the Mycobacterium tuberculosis complex (MTBC). It has variable clinical presentation and is a major cause of morbidity and mortality in the middle-and-low-income-countries (LMICs). Isolated axillary tuberculous lymphadenitis (ATL) is rare and is defined as the presence of axillary tuberculous lymphadenitis in the Continue reading “Isolated axillary tuberculous lymphadenitis in a Nigerian female: A case report with review of the literature”

Isolation of Globicatella sanguinis from a neonate with sepsis using BacT/Alert and VITEK-2 compact system at Federal Teaching Hospital, Katsina, northwest Nigeria: A case report

*[1]Obaro, H. K., [2]Suleiman, M. B., 2Yekinni, S. A., Sanda[3], A., and [4]Aminu, B. T.

1Department of Microbiology, Umaru Musa Yar’adua University, Katsina, Nigeria

2Department of Paediatrics, Federal Teaching Hospital, Katsina, Nigeria

3Department of Clinical Microbiology, Federal Teaching Hospital, Katsina, Nigeria

4Department of Internal Medicine, Federal Teaching Hospital, Katsina, Nigeria *Correspondence to: obarohasan@yahoo.com; +2348136436916

Abstract:

Neonatal sepsis is a significant cause of neonatal morbidity and mortality, predominantly in developing countries. The bacterial causes of neonatal sepsis and their antimicrobial susceptibility patterns are however dynamic. Globicatella sanguinis is a streptococcus-like bacterial agent capable of causing serious infection in humans that has been rarely isolated from clinical samples, and is an uncommon pathogen that is difficult to identify. Continue reading “Isolation of Globicatella sanguinis from a neonate with sepsis using BacT/Alert and VITEK-2 compact system at Federal Teaching Hospital, Katsina, northwest Nigeria: A case report”

Prevalence and antifungal susceptibility pattern of oral candidiasis among HIV-infected patients in a Mission Hospital, southeast Nigeria

*1Ekwealor, C. C., 2Nweke, C. J., 1Anaukwu, C. G., 1Anakwenze, V. N., 1Ogbukagu, C. M., and 3Mba, A. N.

1Department of Applied Microbiology and Brewing, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria

2Department of Basic Clinical Science, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria

3David Umahi Federal University of Health Sciences, Uburu, Ebonyi State, Nigeria

*Correspondence to: c.ekwealor@unizik.edu.ng; +234(0)8035080790; ORCID: 0000-0002-7171-2174

Abstract:  

Background: Oral candidiasis is an infection that follows colonization of oral cavity by Candida species mostly Candida albicans. About 90% of HIV-infected persons develop this disease during the course of HIV infection and could serve as early sign of HIV-related immunodeficiency. Treatment involves the use of antifungal drugs. The objectives of this study are to determine the prevalence of oral candidiasis and the susceptibility of isolated Candida species to available antifungal agents among selected HIV-infected patients in a mission hospital, southeast Nigeria.  Continue reading “Prevalence and antifungal susceptibility pattern of oral candidiasis among HIV-infected patients in a Mission Hospital, southeast Nigeria”

Seroprevalence of transfusion transmissible infections by ELISA in donors testing negative with rapid ICT in Asokoro District Hospital, Abuja, Nigeria

1,2Nwankwo, C. G., 3Obazee, Y. D., 1Sanni, E. O., 4,5Ezike, N. K., *6Adegboro, B., and 7Asalu., A. F.

1Department of Haematology and Transfusion, Nile University of Nigeria, Abuja, Nigeria

2Department of Haematology and Transfusion, Asokoro District Hospital, Abuja, Nigeria

3Medical Laboratory/Blood Banking Service Unit, Asokoro District Hospital, Abuja, Nigeria

4Department of Anatomic Pathology and Forensic Medicine, Nile University of Nigeria, Abuja, Nigeria

5Department of Anatomic Pathology and Forensic Medicine, Asokoro District Hospital, Abuja, Nigeria

*6Department of Medical Microbiology and Immunology, Nile University of Nigeria, Abuja, Nigeria

7Department of Clinical Pharmacology and Therapeutics, Nile University of Nigeria, Abuja, Nigeria

*Correspondence to: boazadegboro@gmail.com; boaz.adegboro@nileuniversity.edu.ng; +2348033812348

 

Abstract:

 Background: Blood transfusion saves lives, but it is associated with many complications which include transfusion transmissible infections (TTIs). The major objectives of this study were to determine; the prevalence of TTIs in the blood donated at Asokoro District Hospital, Abuja, Nigeria from 01 January to 31 December 2019; investigate the accuracy of rapid immunochromatographic (ICT) tests for preliminary TTIs screening of blood donors’ samples and confirmed by ELISA test; and establish baseline data that will provide the impetus for improvement in equipment, infrastructure, and health system management, with the ultimate goal of ensuring safer blood transfusion practice. Continue reading “Seroprevalence of transfusion transmissible infections by ELISA in donors testing negative with rapid ICT in Asokoro District Hospital, Abuja, Nigeria”

Prevalence and risk factors for hepatitis C virus infection among HIV positive patients at the Lagos University Teaching Hospital, Nigeria

*1,2Oshun, P. O., 1,2Salu, O. B., and 1,2Omilabu, S. A.

Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Nigeria

Centre for Human and Zoonotic Virology, College of Medicine, University of Lagos, Nigeria

*Correspondence to: sampydee@yahoo.com

 

Abstract:  

 Background: Worldwide, an estimated 58 million people have chronic hepatitis C virus (HCV) infection, with about 1.5 million new infections occurring per year. About 2.3 million people living with HIV globally have serological evidence of past or present HCV infection. The aim of this study was to determine the prevalence of active HCV infection and associated risk factors among HIV positive patients attending the HIV clinic, Lagos University Teaching Hospital (LUTH), Idi-Araba, Lagos, Nigeria. Continue reading “Prevalence and risk factors for hepatitis C virus infection among HIV positive patients at the Lagos University Teaching Hospital, Nigeria”

The influence of exposure to various concentrations of five antimicrobial agents on intracellular cytotoxin B production in Clostridioides difficile

1Jamal, W., 2Duerden, B. I., and *3Rotimi, V. O.

1Department of Microbiology, College of Medicine, Kuwait University, Kuwait

2Department of Medical Microbiology, University of Wales, Cardiff, United Kingdom

3Center for Infection Control and Patient Safety, College of Medicine University of Lagos, Nigeria

*Correspondence to: bunmivr@yahoo.com

 

Abstract:

 Background: Clostridioides difficile is an important cause of healthcare-associated diarrhea. Several anti- microbial agents are known to promote C. difficile infection (CDI). The impact of various concentrations of ampicillin (AMP), cefotaxime (CTX), clindamycin (CC), metronidazole (MTZ) and vancomycin (VAN) on intracellular cytotoxin B production was investigated in this study. Continue reading “The influence of exposure to various concentrations of five antimicrobial agents on intracellular cytotoxin B production in Clostridioides difficile”

Emergence of New Delhi metallo-β-lactamase-1 (NDM-1) producing Enterobacterales from water sources: an impending public health challenge in Adamawa-north senatorial zone, Nigeria

*[1]Tula, M. Y., [2]Enabulele, O. I., 2Ophori, E. A., 2Okojie, R. O., and [3]Joel, F.

 1Department of Biological Science Technology, Federal Polytechnic Mubi, PMB 035 Mubi, Adamawa State, Nigeria

2Department of Microbiology, Faculty of Life Sciences, University of Benin, Nigeria

3Department of Microbiology, Adamawa State University Mubi, Adamawa State, Nigeria

*Correspondence to: birtyty@gmail.com

Abstract:

Background: The emergence of New Delhi metallo-beta-lactamase-1 (NDM-1) among Enterobacterales in water sources has raised a major public health concern and constitute critical threat to human health as these organisms exhibits high level of resistance to available potent antibiotics. The aim of this study is to detect the presence of NDM1 gene among carbapenem resistant Enterobacterales (CRE) isolates from water sources.   Continue reading “Emergence of New Delhi metallo-β-lactamase-1 (NDM-1) producing Enterobacterales from water sources: an impending public health challenge in Adamawa-north senatorial zone, Nigeria”

Emergence of clinical vanA-type vancomycin-resistant Staphylococcus aureus isolates in National Orthopaedic Hospital Dala, Kano, Nigeria

*[1],3Abdulrahim, U., [2]Oche, D. A., [3]Kachallah, M., 4Adeshina, G. O., and 4Olayinka, B. O.

 1Department of Medical Microbiology, School of Basic Medical Sciences,              Central South University, Hunan Province, China

2Department of Microbiology, Faculty of Science, Federal University of               Health Sciences Otukpo, Benue State, Nigeria

3Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, University of Maiduguri, Borno State, Nigeria                                                  4Department of Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria                       *Correspondence to: uabdulrahim@csu.edu.cn and uabdulrahim@unimaid.edu.ng

Abstract:  

Background: The increasing prevalence of multi drug resistance (MDR) in strains of Staphylococcus aureus is a major challenge in the selection of an appropriate therapeutic agents, especially in persistent orthopaedic infections. This study investigated the patterns of antimicrobial resistance and identified the genetic determinants of resistance in S. aureus isolates from orthopaedic patients. Continue reading “Emergence of clinical vanA-type vancomycin-resistant Staphylococcus aureus isolates in National Orthopaedic Hospital Dala, Kano, Nigeria”

Phenotypic characterization and antimicrobial susceptibility profiles of Vibrio cholerae isolates during the October 2022 and January 2023 outbreak in North-Kivu province, The Democratic Republic of Congo

*1,2Kabangwa, R. K. S., 2Mulasi, K. H., 2Moyengo, B. T., 2Byamungu, J. M.,              and 2Mobile, P. K.

1Department of Biology, University of Goma, Goma, The Democratic Republic of Congo

2Appui Médical Intégré aux Activités de Laboratoire (AMI-LABO), North Kivu Province, Democratic Republic of Congo                                                             *Correspondence to: amilabogm@gmail.com; +243 994 907 798

Abstract:  

Background: Cholera is an infectious disease characterized by severe watery diarrhea, frequently occurring in outbreaks which affects many communities in the Democratic Republic of the Congo (DRC). At the end of October 2022, a cholera outbreak was declared in the camp of internally displaced people (IDP) of Kanyaruchinya, 20 kilometers north of Goma, the provincial capital of the North-Kivu province in DRC, as well as in other IDP camps and settlements around the city of Goma. The aim of this study was to phenotypically characterize Vibrio cholerae isolates associated with this outbreak, and to determinate their antimicrobial susceptibility profiles. Continue reading “Phenotypic characterization and antimicrobial susceptibility profiles of Vibrio cholerae isolates during the October 2022 and January 2023 outbreak in North-Kivu province, The Democratic Republic of Congo”

A review of staphylococcal scalded skin syndrome

1Medugu, N., 1Imran, J., 2Musa-Booth, T. O., 3Makun, B., and *1Adegboro, B.

 1Department of Medical Microbiology and Immunology, Nile University of Nigeria, Abuja, Nigeria

21928 Woodlawn Drive, Woodlawn, Maryland 21207, USA     

3Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria

*Correspondence to: boazadegboro@gmai.com; boaz.adegboro@nileuniversity.edu.ng

Abstract:

Staphylococcal scalded skin syndrome (SSSS) is characterized by widespread epithelial necrosis and/or superficial blistering of the skin following infection by some toxigenic strains of Staphylococcus aureus. The disease primarily affects children under the age of 5 years, but it can also occur in adults. Continue reading “A review of staphylococcal scalded skin syndrome”