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Bacterial profile and antibiogram of clinical isolates in a tertiary healthcare facility in northeast Nigeria: Initial steps towards developing local antibiotic guidelines and antimicrobial stewardship programme

*[1]Manga, M. M., 1Ibrahim, M., [2],[3]Ali, M. W., 4Warnow, I. E., 5Guduf, M. I., 6Farouk, H. U., 1Charanci, M. S., 1Galadima, G. B., and 2,3,7Fadare, J. O.

1Department of Medical Microbiology and Immunology, Gombe State University / Federal Teaching Hospital Gombe, Nigeria

2Department of Clinical Pharmacology and Therapeutics, Gombe State University, Gombe, Nigeria

3Department of Medicine, Federal Teaching Hospital Gombe, Nigeria

4Department of Paediatrics, Gombe State University / Federal Teaching Hospital Gombe, Nigeria

5Department of Surgery, Gombe State University / Federal Teaching Hospital Gombe, Nigeria

6Department of Obstetrics and Gynaecology, Gombe State University / Federal Teaching Hospital Gombe, Nigeria

7Department of Pharmacology and Therapeutics, College of Medicine, Ekiti State University, Ado-Ekiti, Nigeria *Correspondence to: drmmanga@gsu.edu.ng; +2348036781726

Abstract:

Background: Antibiograms and antibiotic guidelines are important tools for appropriate prescribing practices in combating the antimicrobial resistance (AMR) challenge. They serve as a prelude to an evidence-based Antimicrobial Stewardship (AMS) program, which is necessary for better Infection Prevention and Control (IPC) activities, especially in low-resource settings like Nigeria. This study determined the bacterial profile and antibiogram of clinical isolates in a tertiary healthcare facility in Gombe, northeastern Nigeria. Continue reading “Bacterial profile and antibiogram of clinical isolates in a tertiary healthcare facility in northeast Nigeria: Initial steps towards developing local antibiotic guidelines and antimicrobial stewardship programme”

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Empirical antibiotherapy as a potential driver of antibiotic resistance: observations from a point prevalence survey of antibiotic consumption and resistance in Gombe, Nigeria

*1Manga, M. M., 1Ibrahim, M., 2Hassan, U. M., 2Joseph, R. H., 2Muhammad, A. S.,  3Danimo, M. A., 4Ganiyu, O., 5Versporten, A., and 6Oduyebo, O. O.

1Department of Medical Microbiology and Immunology, Gombe State University/ Federal Teaching Hospital, Gombe, Nigeria

2Department of Medical Microbiology and Immunology, Federal Teaching Hospital, Gombe, Nigeria                 

3Department of Community Medicine, Gombe State University/Federal Teaching Hospital, Gombe, Nigeria

4Department of Medicine, Gombe State University/Federal Teaching Hospital, Gombe, Nigeria

5Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium

6Department of Medical Microbiology, University of Lagos/Lagos University Teaching Hospital, Lagos, Nigeria

*Correspondence to: drmmanga@gmail.com

Abstract:

Background: Empirical use of antibiotics is a standard practice in the treatment of infections worldwide. However, its over utilization without subsequent culture and antibiotic susceptibility testing could be a major driver of resistance. Over reliance on empirical antibiotherapy is common in most developing countries where antibiotic policies and availability or utilization of clinical microbiology laboratory are suboptimal. A standardized approach to point prevalence survey (PPS) on antimicrobial use (AMU) in hospitals was employed to assess the antimicrobial prescribing practices in Federal Teaching Hospital Gombe (FTHG), Nigeria.

Methodology: A PPS was conducted in April 2019 at FTHG by recruiting all in-patients present in the hospital on the day of survey. Data obtained from patients’ records included details of the type and indication for antibiotherapy. A customized online application developed by the University of Antwerp (www.global–pps.be) was used for data-entry, validation, analysis and reporting.      Continue reading “Empirical antibiotherapy as a potential driver of antibiotic resistance: observations from a point prevalence survey of antibiotic consumption and resistance in Gombe, Nigeria”

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Antibiogram of Pseudomonas species: an important tool to combat antibiotic resistance for patient safety in Gombe, Nigeria

   1Manga, M. M., *1Ibrahim, M., 2Isaac, E. W., 3Hassan, M. D., 3Muhammad, G.,  3Hassan, U. M., and 4Yunusa-Kaltungo, Z.

1Department of Medical Microbiology and Immunology, Gombe State University/ Federal Teaching Hospital, Gombe, Nigeria

2Infectious Diseases Unit, Department of Paediatrics, Gombe State University/  Federal Teaching Hospital, Gombe, Nigeria

3Department of Medical Microbiology and Immunology, Federal Teaching Hospital, Gombe, Nigeria

4Plastic Surgery Unit, Department of Surgery, Federal Teaching Hospital, Gombe, Nigeria

*Correspondence to: mohgembu@yahoo.com; +2348060232264

Abstract:

Background: Pseudomonas species are responsible for different healthcare-associated infections and are inherently resistant to many commonly used antibiotics. Hospital antibiograms are either absent or not regularly available in most healthcare facilities in Nigeria. The objective of this study is to present the antibiogram of Pseudomonas isolates in Federal Teaching Hospital Gombe (FTHG) in order to guide antibiotic prescription for better patient safety in the hospital.    Continue reading “Antibiogram of Pseudomonas species: an important tool to combat antibiotic resistance for patient safety in Gombe, Nigeria”

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Antimicrobial Stewardship Implementation in Nigerian Hospitals: Gaps and Challenges

*1Iregbu, K. C., 1Nwajiobi-Princewill, P. I., 1Medugu, N., 2Umeokonkwo, C. D., 3Uwaezuoke, N. S., 4Peter, Y. J., 5Nwafia, I. N., 6Eliukwu, C., 7Shettima, S. A., 8Suleiman, M. R., 9Awopeju, T. A., 10Udoh, U., 11Adedosu, N., 12Mohammed, A., 13Oshun, P., 14Ekuma, A., 15Manga, M. M., 16Osaigbovo, I. I., 17Ejembi, C. J., 18Akujobi, C. N., 19Samuel, S. O., 20Taiwo, S. S., and 13Oduyebo, O. O.

1National Hospital Abuja, Nigeria;

2Alex Ekwueme Federal Teaching Hospital, Abakaliki;

3Federal Medical Centre, Jabi, Abuja, Nigeria;

4University of Abuja Teaching Hospital, Gwagwalada;

5University of Nigeria Teaching Hospital, Enugu;

6Babcock University Teaching Hospital, Ilishan-Remo, Nigeria;

7Federal Medical Centre, Yola;

8Federal Medical Centre, Katsina;

9University of Port Harcourt Teaching Hospital, Port Harcourt;

10University of Calabar Teaching Hospital, Calabar;

11Federal Medical Centre, Owo;

12Usmanu Danfodiyo University Teaching Hospital, Sokoto;

13Lagos University Teaching Hospital, Lagos;

14University of Uyo Teaching Hospital, Uyo;

15Federal Teaching Hospital, Gombe;

16University of Benin Teaching Hospital, Benin-City;

17Ahmadu Bello University Teaching Hospital, Zaria;

18Nnamdi Azikiwe University Teaching Hospital, Nnewi;

19Irrua Specialist Teaching Hospital, Irrua;

20Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso, Nigeria. *Correspondence to: keniregbu@yahoo.co.uk

Abstract:
Background: Antimicrobial resistance (AMR) is a major clinical challenge globally. It is mainly a consequence of inappropriate prescribing and use of antibiotics. Antimicrobial stewardship (AMS) ensures that antibiotics are prescribed and used appropriately. This study assessed AMS practice in selected Nigerian hospitals. Continue reading “Antimicrobial Stewardship Implementation in Nigerian Hospitals: Gaps and Challenges”