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A review of the implications of Lactic Acid Bacteria and Bifidobacteria in human and animal diseases

*1Bamidele, T. A., 2Odumosu, B. T., 3Shittu, O. B., 4Adeniyi, B. A., and 5Ogunshe, A. O.

*1Department of Molecular Biology and Biotechnology, Nigerian Institute of Medical Research, Lagos, Nigeria

2Department of Microbiology, Faculty of Science, University of Lagos, Akoka-Yaba, Lagos, Nigeria

3Department of Microbiology, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria

4Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Nigeria

5Department of Microbiology, Faculty of Applied Sciences, Koladaisi University, Ibadan, Nigeria *Correspondence to: deletaju@yahoo.co.uk; +2348038578093; ORCID: //orcid.org/0000-0003-2155-8639

Abstract:
Lactic acid bacteria (LAB) and Bifidobacteria are taxonomically distinct groups of bacteria with proven biotechnological properties such as anti-cancer, immune-stimulating, anti-microbial, maintenance of normal flora balance, probiotics, anti-inflammatory, vaccine carriers, among others. However, studies have implicated some of them, including the ones under the European Food Safety Authority (EFSA) qualified presumption of safety in fatal human and veterinary diseases. We performed online database searches of publications on Google, Google Scholar and PubMed using the criteria, “lactic acid bacteria, bifidobacteria as causative agents of human, animal diseases”. Data generated showed LAB across genera and Bifidobacteria either primarily or opportunistically involved in diseases of both immuno-competent and immuno-depressed humans and animals. The members of lactobacilli such as Lactobacillus fermentum, Lactobacillus paracasei, Lactobacillus oris, Lactobacillus gasseri and Leuconostoc mesenteroides, were mainly implicated in nosocomial infections, endophthalmitis, neonatal meningitis, and bacteraemia while Lactobacillus delbrueckii and Bifidobacteria, specifically, Bifidobacterium longum, Bifidobacterium breve, and Bifidobacterium animalis were implicated in urinary tract infections (UTIs), necrotizing pancreatitis, fatal pulmonary infections, sepsis, and epidural abscess. The animal diseases, neonatal sepsis in foal, was caused by Weissella confusa while the fish pathogen, Lactococcus garvieae caused various zoonotic cases such as acute acalculous cholecystitis in human. In conclusion, this review showed the up-to-date reports on LAB and Bifidobacteria implicated in serious humans and animal diseases. Continue reading “A review of the implications of Lactic Acid Bacteria and Bifidobacteria in human and animal diseases”

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Bacteriological analysis of well water samples in Sagamu

AO Idowu, BB Oluremi, KM Odubawo

 

Abstract

Majority of the population in semi-urban and urban areas of Nigeria depend on wells as their source of water supply. Due to increasing cases of water-borne diseases in recent times, this study was carried out to examine the microbial quality of well water in Sagamu, Nigeria as a way of safeguarding public health against water borne diseases. Water samples from a total of forty wells, covered and uncovered from four different locations of varying socio economic and demographic status were assessed for their bacteriological quality using serial dilution to obtain total bacteria count and the multiple tube fermentation technique to determine the coliform count using the most probable number method. Positive tubes of the presumptive test were further cultured on appropriate solid media. The organisms isolated were further characterized using standard procedures. The result of the study revealed that all the wells were grossly contaminated with bacteria pathogens such as Klebsiella spp (95%), Escherichia coli (72%) and Salmonella typhi (32.5%). Comparatively, the uncovered wells were more highly contaminated with bacteria pathogens than the covered well especially in the highly populated areas. All the water samples exceeded the standard limit of the most probable number (MPN) per 100ml set for untreated drinking water. This result highlight the fact that most well water in Sagamu metropolis are not safe microbiologically for drinking without additional treatment such as boiling or disinfection and this could lead to outbreak of water borne diseases. Good and proper environmental and personal hygiene must be maintained especially by the users of those wells to prevent their contamination with bacterial pathogens.

Keywords: Well water, bacteriological analysis, bacterial pathogens, water borne, diseases

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Bacteriological analysis of well water samples in Sagamu