[1],[2]Soré, S., 3Sanou, S., 3Sawadogo, Y., 1Béogo, S., 3Dakouo, S. N. P., 4Djamalladine, M. D., 1lboudo K. S., 2Ouoba, B., ³Zoungrana, J., ³Poda, A., 2Ouédraogo, A. S., and 1,2Sanou
1Tengandogo University Hospital, Ouagadougou, Burkina Faso
2Saint Thomas d’Aquin University, Doctoral School of Science, Health and Technology, Burkina Faso
3Souro Sanou University Hospital, Bobo-Dioulasso, Burkina Faso
4National Higher Institute of Science and Technology of Abeche, Abeche, Chad
*Correspondence to: soulsore11@yahoo.fr; (00 226) 72 04 29 15
Abstract:
Background: Extended spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) are a serious challenge to patients’ treatment. The aim of this study is to determine the prevalence of ESBL-PE, investigate the associated resistance, and analyze the associated risk factors for acquisition of ESBL-PE.
Methodology: A cross-sectional study was conducted on healthy volunteers and inpatients. After obtaining informed consent, rectal swabs were collected from each participant for isolation of Enterobacteriaceae on Hektoen enteric agar containing 4µg/L cefotaxime. The Enterobacteriaceae isolates were identified using biochemical tests and ESBL production was confirmed by the double-disc synergy test of amoxicillin and clavulanic acid. Antibiotic susceptibility test of each isolate was done by the disc diffusion method and interpreted using the recommendations of the European Committee on Antimicrobial Susceptibility Testing (EUCAST) clinical breakpoints version 5.0. Continue reading “Faecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae in healthy volunteers and hospitalized patients in Ouagadougou, Burkina Faso: prevalence, resistance profile, and associated risk factors”