*1,2,4Fayemiwo, S. A., 1,2Makanjuola, O. B., 1Nwaokenye, J., and 3Owolabi, M. O.
1Department of Medical Microbiology and Parasitology, University College Hospital, Ibadan, Nigeria
2Department of Medical Microbiology and Parasitology, College of Medicine, University of Ibadan, Ibadan, Nigeria
3Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria
4Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, M13 9PL, UK
*Correspondence to: dayteet@yahoo.com
Abstract:
Background: A number of studies have been conducted in Nigeria on the prevalence of cryptococcal infections mostly on HIV-infected patients using culture, India ink and/or latex agglutination tests. These tests are either laborious, time-consuming and expensive or have low sensitivity, thus limiting their use. Cryptococcal antigen lateral flow assays (LFA) were introduced in the last decade as rapid user-friendly tests for diagnosis. In this study, we sought to determine the diagnostic accuracy of an LFA kit for the detection of cryptococcal antigen in the serum of HIV-negative patients with or without cerebrovascular accident (CVA) or stroke in University College Hospital, Ibadan, Nigeria. Continue reading “Evaluation of a cryptococcal antigen lateral flow assay test for rapid detection of cryptococcal infection in HIV-negative patients in Ibadan, Nigeria”