1Obidi N. O., and 2Ekpunobi, N. F.
1Department of Parasitology, Nnamdi Azikiwe University, Awka, Nigeria
2Department of Pharmaceutical Microbiology and Biotechnology, Nnamdi Azikiwe University, Awka, Nigeria
*Correspondence to: nzubefavour34@gmail.com
Abstract:
The increasing threat of antimicrobial resistance (AMR) in Africa, coupled with limited access to advanced antibiotics and high rates of bacterial infections poses serious public health challenge. Bacteriophages, viruses that target and destroy bacteria, present a promising alternative or complementary therapy to traditional antibiotics. Phage therapy leverages its unique ability to target specific bacterial strains without affecting the host beneficial microbiota. It is an effective tool against multi-drug-resistant (MDR) microbial pathogens, particularly in resource-limited settings. This narrative review explores the potentials of phage therapy in Africa, highlighting its advantages, such as specificity, minimal side effects, and cost-effectiveness, alongside its capability to tackle biofilm-associated and AMR infections. It discusses current research and collaborations, including case studies from Nigeria, Benin, and South Africa that demonstrate the efficacy of phage therapy against bacterial pathogens such as Escherichia coli, Acinetobacter baumannii and Klebsiella pneumoniae. Furthermore, it discusses the challenges to phage therapy implementation such as regulatory hurdles, public skepticism, and infrastructure limitations, while emphasizing the importance of developing local production and awareness campaigns. The review concludes by recommending the integration of phage therapy into Africa healthcare strategies to address AMR. Through strategic partnerships, education and regulatory frameworks, phage therapy could become a transformative solution, particularly for neglected diseases and infections common in low-resource settings. As Africa seeks innovative approaches to its growing AMR crisis, phage therapy stands out as a viable and adaptable option.
Keywords: Bacteriophage, therapy, application, antimicrobial resistance, review, Africa
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