Posted on

Exploring the antimicrobial potential of Azadirachta indica (Neem) phytoconstituents against drug-resistant Acinetobacter baumannii: A molecular docking and ADMET screening study

Adewole, P. D., *Oluwafemi, I. B., and Bamigboye, K. P.  

 Medical Laboratory Science Programme, College of Health Sciences, Bowen University, Iwo, Osun State, Nigeria Department of Medical Microbiology and Parasitology, Faculty of Medical Laboratory Science, University of Ilesa, Ilesa, Osun State, Nigeria

*Correspondence to: oluwafemi.inioluwa@bowen.edu.ng; 07026731414; ORCID: https://orcid.org/0009–0006–8086–1637

 

Abstract:

 

Background: The emergence of multidrug resistant (MDR) Acinetobacter baumannii remains at the top of the health care concern around the world which thereby emphasizes the need to discover novel antimicrobials from medicinal plants, such as Azadirachta indica (neem) in treatment of infections caused by MDR A. baumannii. The current insilico study was aimed to evaluate inhibitory potential of Neem derived phytoconstituents against essential proteins of A. baumannii and their evaluation of pharmacokinetic characteristics.                 Continue reading “Exploring the antimicrobial potential of Azadirachta indica (Neem) phytoconstituents against drug-resistant Acinetobacter baumannii: A molecular docking and ADMET screening study”

Posted on

Antibiotic susceptibility of bacteria isolated from suppurative acute otitis media in children in Ouagadougou, Burkina Faso  

[1],3Tondé, I., [2]Guiguemdé, K. T., *[3],[4]Condé, M. S., 2Savadogo, P. M., 2,3Sanogo, Z., 1,3Tapsoba, A., 3Tamboura, M., 2,3Soma, W., 1Béré, P. L., 3Somé, C. K., 1Ky/Ba, A., 1Sanou, I., and [5]Gyebré, Y. M. C.

1Laboratory of Bacteriology-Virology, UFR SDS, Joseph Ki-Zerbo Université, Ouagadougou, Burkina Faso

2Laboratory of Parasitology-Mycology, UFR SDS, Joseph Ki-Zerbo Université, Ouagadougou, Burkina Faso

3Department of Biomedical Analysis Laboratory, Charles de Gaulle Pediatric University Hospital, Ouagadougou, Burkina Faso

4Department of Biomedical Analysis Laboratory, Ignace Deen University Hospital, Conakry Guinea

5Department of Otolaryngology, Yalgado Ouédraogo University Hospital, Ouagadougou, Burkina Faso *Correspondence to: mamadisaran93@gmail.com; Tel: (226) 64645543

Abstract:

Background: Acute otitis media (AOM) is one of the most common bacterial infections in children. The emergence of antimicrobial resistance (AMR) poses a threat to the management of these infections. The objective of this study was to identify and describe the sensitivity profile of bacterial agents isolated in AOM to commonly used antibiotics in the city of Ouagadougou, Burkina Faso.                            Continue reading “Antibiotic susceptibility of bacteria isolated from suppurative acute otitis media in children in Ouagadougou, Burkina Faso  “