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Prevalence of extended spectrum β-lactamase genes among multi-drug resistant Klebsiella pneumoniae isolates from clinical specimens in Calabar, Nigeria

*1Ukam, I. I., 1Iyam, S. O., 1Ugbadu, J. I., 2Unoh, F. B., 1Ukeye, A. A., 1Okoro B. C., 1Akpeke, V. U., and 3Umoh, N. O.

1Department of Microbiology, Faculty of Biological Sciences, University of Calabar, PMB 1115 Calabar, Nigeria

2Department of Science Laboratory Technology, Faculty of Biological Sciences, University of Calabar, PMB 1115 Calabar, Nigeria

3Department of Bacteriology, Virology and Mycology, Faculty of Medical Laboratory Science, University of Calabar, PMB 1115, Calabar, Nigeria

*Correspondence to: ukamjohn8@gmail.com & igborukam@unical.edu.ng; Mobile: +2349074254995/ +2348032327041; ORCiD ID: 0009-0005-7645-5508

Abstract:

Background: The global spread of the extended spectrum beta-lactamases (ESβL) and carbapenemases producing strains of Klebsiella pneumoniae constitutes a public health threat to both humans and animals. This study investigated the prevalence of ESβLs genes among multidrug resistant (MDR) K. pneumoniae isolates from clinical specimens of patients attending selected hospitals in Calabar, Nigeria. Continue reading “Prevalence of extended spectrum β-lactamase genes among multi-drug resistant Klebsiella pneumoniae isolates from clinical specimens in Calabar, Nigeria”

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Prevalence of β-lactamase-encoding genes in Salmonella Typhi isolates from patients attending secondary healthcare facilities in Benue south senatorial district, northcentral Nigeria

[1],[2],[3]Adikwu, P., *1Oche, D. A., 2Umeh, E. U., 2Ogbonna, I. O., 2Iheukwumere, C. C., [4]Obande, G. A., [5]Oyiwona, G. E., 2Adole, P. I., 1Agbo, A. A., 2Ochekpe, S. O., 3Okoh, M. E., and 3Soom, S. T.

[1] Département de Microbiologie, Faculté des Sciences, Université Fédérale des Sciences de la Santé d’Otukpo, État de Benue, Nigéria

[2] Département de Microbiologie, Université Fédérale d’Agriculture, Makurdi, État de Benue, Nigéria

[3] 3Département de Microbiologie, Université d’État de Benue Makurdi, État de Benue, Nigéria

[4] 4Département de Microbiologie, Université Fédérale, Lafia, État de Nasarawa, Nigéria

[5] Département de Technologie de Laboratoire Scientifique, École Polytechnique de l’État de Benue, Ugbokolo,

Abstract:

 Background: The emergence of multi-drug resistant (MDR) Salmonella Typhi poses a major challenge in the treatment of typhoid fever using commonly available antibiotics. However, in many rural and semi-urban communities of low- and middle-income countries (LMICs), routine surveillance for MDR S. Typhi is scarcely undertaken. The aim of this study is to determine the prevalence of β-lactamase genes in MDR S. Typhi isolated from patients in nine secondary healthcare facilities in Benue south senatorial district, northcentral Nigeria. Continue reading “Prevalence of β-lactamase-encoding genes in Salmonella Typhi isolates from patients attending secondary healthcare facilities in Benue south senatorial district, northcentral Nigeria”