Cancer – afrjcem.org

^*1,2Adewole, O. E., ¹Jonathan, S. G., ³Olorunmola, F. O., ⁴Owotade, F. J., ⁵Gbolagade-Jonathan, P. T., ⁶Odetoyin, B. W., and ⁶Olaniran, O.

¹Mycology and Applied Microbiology Research Group, Department of Botany, Faculty of Science, University of Ibadan, Nigeria

²Department of Microbiology, Faculty of Sciences, University of Ilesa, Ilesa, Nigeria

³Department of Drugs Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria

⁴Department of Oral Medicine and Oral Pathology, Faculty of Dentistry, Obafemi Awolowo University, Ile-Ife, Nigeria

⁵Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan. Ibadan, Nigeria

⁶Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria

*Correspondence to: oeadewole@yahoo.com, +2347063352347, ORCiD: 0000000177125037

Abstract:

Background: Candida species inhabit humans as commensals but become opportunistic pathogens in immunocompromised individuals. This yeast has developed resistance to anti-fungal medications and infection caused by it is associated with increased morbidity and mortality. Information on the yeast colonization profile and the antifungal sensitivity pattern in the Nigerian population is sparse. This study determined the prevalence and antifungal susceptibility patterns of oral Candida species among cancer patients attending two tertiary care hospitals in Osun State, southwest Nigeria. Continue reading “Antifungal susceptibility patterns of Candida species colonizing the oral cavity of cancer patients attending two tertiary hospitals in southwest Nigeria”

SH Afraseyabi, A Afkhamzadeh, H Sabori, F Verdi, N Khaksar, B Mosavei, E Kalantar

Abstract

Background: Within the past two decades, Candida species have emerged as major human pathogens and are currently the fourth most common cause of nosocomial infection. Propose of this study was to determine the occurrence of oral Candidiasis among cancer patients at Qods hospitals in Sanandaj.
Materials and Methods: Sixty cancer patients were examined for oral candidiasis. For all patients, the clinical diagnosis had to be confirmed microbiologically by the presence of yeasts and / or hyphae or pseudohyphae on potassium hydroxide–treated smears of oral swabs. Oral samples were obtained and cultured on Sabouraud’s dextrose agar and CHROMagar.
Results: 25 out of the 60 patients (41.7%) were males and 35 (58.3%) were females ranging in age from 15 to 79 years. Gastrointestinal cancer and Breast cancer were the most frequent cancer in the studied group, accounting for 65 % and 18.4 % respectively. The mean weight of the patients was 52.67 Kg (range, 38– 80 Kg). Similarly, the mean of hospital stay was 3.58 days (range; 1-9 days). From these patients, 19 Candida spp were isolated; C. albicans alone outnumbered other species and accounted for 73.68% episodes of trash. For C. albicans isolates, the MIC values ranges from 1 to 9 Z g / ml μg / ml for polyenes and from 0.03 to 16 Z g / ml for the azole antifungals. All the Candida albicans had closely related MFCs values.
Conclusion: In conclusions, the finding of our study strongly suggest that oral candidiasis is a frequent complication among cancer patients, being C. albicans the main etiological agent.

Keywords: Cancer, Oral candidiasis, Candida albicans, Antifungal agents

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Oral Candidiasis amongst cancer patients at Qods Hospital