*Eze, I. F 0009-0007-7286-9273., Adeoye-Isijola, M. O 0000-0002-3186-5432., Adefisoye, M. A 0000-0002-4957-4609., and Olajuyigbe, O. O 0000-0002-7889-0416
Department of Microbiology, School of Science and Technology, Babcock University, Ogun State, Nigeria *Correspondence to: ezeifyfaith@gmail.com
Abstract:
Metallo-β-lactamases are different types of biological enzymes that breakdown a broad spectrum of beta-lactam antibiotics such as carbapenems. Antibiotic resistance exhibited by many Gram-negative bacteria is due to acquisition of genes encoding these enzymes, which underscores their importance in antibiotic resistance and has led to an increase in nosocomial infections caused by multi-drug-resistant pathogens. This review analyzes recent updates on the mechanism of antibiotic resistance and epidemiology of metallo-β- lactamases in nosocomial infections. Carbapenem antibiotics are regarded as effective and reserve antibiotics for the treatment of multidrug-resistant bacteria infections. Currently, there is paucity of inhibitors that prevent the activities of metallo beta-lactamase clinically. Carbapenem resistance in bacteria is a global health issue, associated with increased morbidity and mortality in the healthcare setting. There is a need for continuous research on metallo-β-lactamases inhibitors, rational use of carbapenems and appropriate infection control measures in order to curb the increase in infections. This mini-review is aimed to provide a broader scope on the current trends of antimicrobial resistance in metallo-β-lactamase-associated nosocomial infections. This will lead to a better understanding of the public health implication of the unabated spread of these infections, the need for judicious utilization of the limited therapeutic options, resulting to efficient antimicrobial stewardship. Continue reading “Recent update on the mechanism and epidemiology of metallo-β-lactamases in nosocomial infections: A mini review”