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Molecular detection of carbapenemase-producing Klebsiella spp from clinical samples in Ibadan, Nigeria

*[1],3Subulade, A. A., 1,[2]Makanjuola, O. B., 2Oduola, A. B., 1,2Adebiyi, I., [3]Azuh, V. O.,                    and 1,2Kehinde, A. O.

  1Department of Medical Microbiology and Parasitology, University of Ibadan, Oyo State, Nigeria

2University College Hospital, Ibadan, Oyo State, Nigeria                              3Biorepository and Clinical Virology Laboratory, College of Medicine, University of Ibadan, Nigeria

*Correspondence to: adeolaasubulade@gmail.com

Abstract:

Background: Klebsiella species are significant pathogens responsible for various healthcare-associated infections. Despite the existence of several mechanisms of resistance against high priority antibiotics such as carbapenems, the production of carbapenemases remains the most important mechanism of resistance among Klebsiella spp. The aim of this study was to determine the prevalence of carbapenemase-production among Klebsiella spp isolated from clinical specimens at the University College Hospital (UCH) Ibadan, Nigeria. Continue reading “Molecular detection of carbapenemase-producing Klebsiella spp from clinical samples in Ibadan, Nigeria”

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Prevalence of carbapenemase production in Pseudomonas aeruginosa isolates causing clinical infections in Lagos University Teaching Hospital, Nigeria

1Ettu, A. O., *2Oladapo, B. A., and 2Oduyebo, O., O.
1Department of Medical Microbiology and Parasitology, Lagos University Teaching Hospital, Nigeria
2Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Nigeria

*Correspondence to: princesscathy1@yahoo.com; 08053505952

Abstract:
Background: Pseudomonas aeruginosa has been highly associated with carbapenem resistance in which carbapenemases has been suggested to be a major contributory factor. Hence the objective of this study was to phenotypically detect KPC-type carbapenemase, metallo-β-lactamase and OXA-48 carbapenemase production in clinical isolates of P. aeruginosa in Lagos University Teaching Hospital (LUTH), Nigeria Continue reading “Prevalence of carbapenemase production in Pseudomonas aeruginosa isolates causing clinical infections in Lagos University Teaching Hospital, Nigeria”

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ESβL, AmpC and carbapenemase co-production in multi-drug resistant Gram-negative bacteria from HIV-infected patients in southwestern Nigeria

*Adeyemi, F. M., and Akinde, S. B.
Department of Microbiology, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria *Correspondence to: folasade.adeyemi@uniosun.edu.ng; +234 803 494 0747

Abstract:
Background: The rising global emergence of Gram-negative bacteria (GNB) producing β-lactam hydrolysing enzymes in clinical infections constitutes a growing public health threat. This study investigated the occurrence of co-production of extended spectrum β-lactamase (ESβL), AmpC β-lactamases, and carbapenemases among GNB isolated from HIV-infected patients in two tertiary healthcare facilities in southwest Nigeria. Continue reading “ESβL, AmpC and carbapenemase co-production in multi-drug resistant Gram-negative bacteria from HIV-infected patients in southwestern Nigeria”