*1,2Sineque, A., 1Condo, T., 3Sebastião, J., 3Nhambe, C., 4Manuel, M., 1Mabasso, A., 3Sidumo, Z., 5Ceffa, S., and 5,6Ciccacci, F.
1Department of Biological Sciences, Faculty of Science, Eduardo Mondlane University, Maputo, Mozambique
2Centre for Functional Ecology–One Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal
3DREAM Program, Community of Saint’Egidio, Maputo, Mozambique
4Laboratory of Mavalane General Hospital, Maputo, Mozambique
5DREAM Program, Community of Saint’Egidio, Roma, Italy
6University of Rome Tor Vergata, Department of Biomedicine and Prevention, Rome, Italy
*Correspondence to: sineque.alberto@uem.ac.mz; Tel: +258 826 459 243; ORCiD: https://orcid.org/0000–0003–2468–9925
Abstract:
Background: High-risk (hr) human papillomaviruses (HPV) testing is immensely important in elucidating molecular epidemiology of HPV infections and has become an essential part of current clinical practice in the management of the precancerous lesions and cervical cancer risks. Evaluation of HPV testing systems suitable for large-scale organized cervical screening programs is required. Very little is known about the diagnostic performance of the Cobas assays in resource-limited settings, particularly in Mozambique. We evaluated the concordance of the Cobas 4800 and Cobas 5800 assays with the Cobas 6800 assay for detecting high-risk HPV genotypes in clinician-collected cervical samples. Continue reading “Comparative performance of Cobas 4800 and 5800 assays with Cobas 6800 assay for detecting/genotyping high-risk HPV in cervical samples: An interlaboratory evaluation in Maputo, Mozambique”