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Microbiological profile of bacteraemia in febrile patients receiving chemotherapy: Experience of the Alassane Ouattara National Center of Oncology and Radiotherapy (CNRAO), 2024

*1,2Boni, C., 1Kouakou, C., 2Gnegouri, R., 2Benié Ackah, J., and 1Koffi, K. S.

1Department of Fundamental and Biological Sciences, Faculty of Medical Sciences, Félix Houphouët-Boigny University, Abidjan, Côte d’Ivoire

2Laboratory Department, Alassane Ouattara National Center of Oncology and Radiotherapy (CNRAO), Abidjan, Côte d’Ivoire

*Correspondence to: boni.cho@ufhb.edu.ci; +2250505083523

 

Abstract:

 Background: Febrile episodes in patients undergoing chemotherapy pose a major risk for bloodstream infections (BSIs). Prompt microbiological diagnosis is essential to guide targeted therapy and minimize the emergence of antimicrobial resistance.

Methodology: A six-month cross-sectional study (July–December 2024) was conducted at the Alassane Ouattara National Center of Oncology and Radiotherapy (CNRAO), Abidjan, Côte d’Ivoire. All chemotherapy patients presenting with fever (≥38.5°C) were included. Blood cultures were processed using the BACT/ALERT system, and bacterial identification with antimicrobial susceptibility testing followed CA-SFM 2022 guidelines. ESBL and carbapenemase production in Gram-negative isolates was detected in line with CA-SFM/EUCAST guidelines while methicillin resistance (MR), macrolide-lincosamide-streptogramin B (MLSB), and kanamycin-tobramycin-genta- micin (KTG) resistance phenotypes in Gram-positive isolates were detected in line with CLSI/CA-SFM standard. Continue reading “Microbiological profile of bacteraemia in febrile patients receiving chemotherapy: Experience of the Alassane Ouattara National Center of Oncology and Radiotherapy (CNRAO), 2024”

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Leptospira sp and chronic kidney disease: A preliminary study of the serological status of a population of dialysis patients in Abidjan, Côte d’Ivoire

*1,2,3Koffi, K. S., 1Bahi, G. A., 1Saraka, N. D., 1Tiémoko, G. G., 1Kouassi, K. S., 1,2Méité, S., and 1Dosso, M.

1Institut Pasteur de Côte d’Ivoire, 01 BP 490, Abidjan 01, Côte d’Ivoire

2Unité de Formation et de Recherche Sciences Médicales, Université Félix Houphouët-Boigny

3Service de Bactériologie-Virologie, CHU de Treichville

*Correspondence to: Koffi.ks@ufhb.edu.ci

Abstract:

Background: Pathogenic strains of Leptospira are responsible for leptospirosis, a neglected zoonotic disease, whose pathophysiology involves acute kidney injury. These kidney lesions may progress to chronic forms, suggesting that leptospirosis could be a potential contributor to chronic kidney disease (CKD). This study aimed to determine the serological status related to leptospirosis in dialysis patients in Côte d’Ivoire.  Continue reading “Leptospira sp and chronic kidney disease: A preliminary study of the serological status of a population of dialysis patients in Abidjan, Côte d’Ivoire”

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Prevalence and aetiological agents of childhood urinary tract infections at the University Teaching Hospital (CHU) of Bouaké, Côte d’Ivoire

*1,2Gawa, K. J., 1,2Monemo, P., 1,2N’Guessan, M., 1,2Tadet, J. O. N., 3Oka, K. H.,         3Akanji, I. A., 3Koné, M. O., 1Vaho, M., 1Traoré, F., and 1,2Akoua Koffi, C.

 1Laboratoire Bactériologie-Virologie, Centre Hospitalier et Universitaire de Bouaké, Côte d’Ivoire

2UFR des Sciences Médical, Université Alassane Ouattara, BP 1174 Bouaké, Côte d’Ivoire

3Service de Pédiatrie Médicale, Centre Hospitalier et Universitaire de Bouaké, Côte d’Ivoire *Correspondant à: kokoragawa@gmail.com; +2250709885690

 

Abstract:

 Background: Urinary tract infections (UTIs) are common in paediatric environment. The microbial ecology is often modified by over-prescription of antibiotics. The aim of this study was to determine the prevalence and etiological agents responsible for paediatric UTIs, with a view to improving care for children in Bouaké, Côte d’Ivoire. Continue reading “Prevalence and aetiological agents of childhood urinary tract infections at the University Teaching Hospital (CHU) of Bouaké, Côte d’Ivoire”

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Investigation of rodent reservoirs of emerging pathogens in Côte d’Ivoire, West Africa

 

*1,2Meite, S., 1,2Koffi, K. S., 1Kouassi, K. S., 1Coulibaly, K. J., 1Koffi, K. E., 1Sylla, A., 1Sylla, Y., 1,2Faye-Ketté, H., and 1,2Dosso, M.

 

1Molecular Biology Platform and Environnement and Health Department, Pasteur Institute, Cote d’Ivoire 2Medical Sciences, Microbiology department, Felix Houphouet Boigny University, Cocody, Abidjan *Correspondence to: meitesynd@yahoo.fr

Abstract:

Background: One of the main health problems in West Africa remains upsurge of emerging pathogens. Ebola virus disease outbreak occurred in 2014 in Liberia, Guinea and Sierra Leone, Monkeypox virus in Nigeria in 2017 and most recently Lassa virus in Nigeria, Togo and Benin in 2018. These pathogens have animal reservoirs as vectors for transmission. Proper investigation of the pathogens in their rodent vectors could help reduce and manage their emergence and spread. Continue reading “Investigation of rodent reservoirs of emerging pathogens in Côte d’Ivoire, West Africa”