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Antifungal susceptibility patterns of Candida species colonizing the oral cavity of cancer patients attending two tertiary hospitals in southwest Nigeria

*1,2Adewole, O. E., 1Jonathan, S. G., 3Olorunmola, F. O., 4Owotade, F. J., 5Gbolagade-Jonathan, P. T., 6Odetoyin, B. W., and 6Olaniran, O.

1Mycology and Applied Microbiology Research Group, Department of Botany, Faculty of Science, University of Ibadan, Nigeria

2Department of Microbiology, Faculty of Sciences, University of Ilesa, Ilesa, Nigeria

3Department of Drugs Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria

4Department of Oral Medicine and Oral Pathology, Faculty of Dentistry, Obafemi Awolowo University, Ile-Ife, Nigeria

5Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan. Ibadan, Nigeria

6Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria

*Correspondence to: oeadewole@yahoo.com, +2347063352347, ORCiD: 0000000177125037

Abstract:

 Background: Candida species inhabit humans as commensals but become opportunistic pathogens in immunocompromised individuals. This yeast has developed resistance to anti-fungal medications and infection caused by it is associated with increased morbidity and mortality. Information on the yeast colonization profile and the antifungal sensitivity pattern in the Nigerian population is sparse. This study determined the prevalence and antifungal susceptibility patterns of oral Candida species among cancer patients attending two tertiary care hospitals in Osun State, southwest Nigeria. Continue reading “Antifungal susceptibility patterns of Candida species colonizing the oral cavity of cancer patients attending two tertiary hospitals in southwest Nigeria”

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Candida bloodstream infection among immunocompromised paediatric patients admitted to the University College Hospital, Ibadan, Nigeria

*1Anozie, C. E., 2Okesola, A., 3Makanjuola, O., 4Ayanbekun, T., 5Mohammed, A. R., and 6Fasuyi, T.

1Department of Medical Microbiology, Federal Medical Centre, Umuahia, Nigeria

2Department of Medical Microbiology and Parasitology, University College Hospital Ibadan, Nigeria

3Department of Medical Microbiology and Parasitology, University College Hospital Ibadan, Nigeria

4Department of Medical Microbiology, Federal Medical Centre, Bida, Niger State, Nigeria

5Department of Medical Microbiology, Lead City University, Ibadan, Nigeria 6Department of Medical Microbiology, Babcock University, Ilishan Remo, Ogun State, Nigeria

*Correspondence to: anoziechikezie@gmail.com; 08035607642

Abstract:
Background: Invasive candidiasis is a major hospital acquired fungal infection in Nigeria. Despite advances in support of critically ill patients, candidaemia is still associated with high morbidity and mortality. Data on Candida bloodstream infection among paediatric patients is limited in Nigeria and this informed this study, which was undertaken to investigate the prevalence, species distribution, antifungal susceptibility pattern for blood stream infections due to Candida species in University College Hospital, Ibadan, Nigeria. Continue reading “Candida bloodstream infection among immunocompromised paediatric patients admitted to the University College Hospital, Ibadan, Nigeria”