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Phenotypic and molecular detection of methicillin-resistance and virulence factors in coagulase-negative staphylococci isolated from patients with urinary tract infections in southeastern Nigeria

*1Ikeagwu, I. J., 2,3Oshim, I. O., 4Obi, C. M., 5Odeyemi, O., 4Urama, E. U., 6Ikeagwulonu, C. R., 2,7Azi, S. O., 2,7Aniokete, U. C., 4Okeke-Nwolisa, B. C., and 2,3Okekpa,S. I.

1Department of Applied Microbiology, Faculty of Science, Ebonyi State University, Nigeria

2Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, David Umahi Federal University of Health Science, Uburu, Ebonyi State, Nigeria

3International Institute for Oncology and Cancer, Uburu, Ebonyi State, Nigeria

4Department of Medical Microbiology and Public Health, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria

5Department of Medical Microbiology and Parasitology, Faculty of Medical Laboratory Science, Achiever University, Owo, Ondo State, Nigeria

6Department of Medical Laboratory Science, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State, Nigeria

7International Institute of Infectious Disease, Biosafety and Biosecurity, Uburu, Ebonyi State, Nigeria

*Correspondence to: judithfmc@gmail.com

Abstract:

Background: The emergence of antibiotic resistance among coagulase-negative staphylococci (CoNS) is an important factor in nosocomial infections outcomes in the healthcare system. This study aimed to phenotypically detect methicillin resistance and genotypically detect mecA gene and other virulence markers in coagulasenegative staphylococci isolated from patients with suspected urinary tract infection (UTI) in Alex Ekwueme Federal University Teaching Hospital (AE-FUTHA), Abakaliki, Ebonyi State, Nigeria. Continue reading “Phenotypic and molecular detection of methicillin-resistance and virulence factors in coagulase-negative staphylococci isolated from patients with urinary tract infections in southeastern Nigeria”

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Emergence of clinical vanA-type vancomycin-resistant Staphylococcus aureus isolates in National Orthopaedic Hospital Dala, Kano, Nigeria

*[1],3Abdulrahim, U., [2]Oche, D. A., [3]Kachallah, M., 4Adeshina, G. O., and 4Olayinka, B. O.

 1Department of Medical Microbiology, School of Basic Medical Sciences,              Central South University, Hunan Province, China

2Department of Microbiology, Faculty of Science, Federal University of               Health Sciences Otukpo, Benue State, Nigeria

3Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, University of Maiduguri, Borno State, Nigeria                                                  4Department of Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria                       *Correspondence to: uabdulrahim@csu.edu.cn and uabdulrahim@unimaid.edu.ng

Abstract:  

Background: The increasing prevalence of multi drug resistance (MDR) in strains of Staphylococcus aureus is a major challenge in the selection of an appropriate therapeutic agents, especially in persistent orthopaedic infections. This study investigated the patterns of antimicrobial resistance and identified the genetic determinants of resistance in S. aureus isolates from orthopaedic patients. Continue reading “Emergence of clinical vanA-type vancomycin-resistant Staphylococcus aureus isolates in National Orthopaedic Hospital Dala, Kano, Nigeria”