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Exploring lytic Salmonella phages as potential alternatives to antibiotics: Isolation, characterization, and stability assessment of Jerseyvirus Ijeoma and Apdecimavirus Ayanbimpe

*[1],[2]Olorundare, O. O., [3],4Nnadi, N. E., 1Nimzing, L., 1Ayanbimpe, G. M.

1Department of Medical Microbiology, Faculty of Basic Clinical Science, University of Jos, Plateau State, Nigeria

2Department of Pest Management Technology, Federal College of Forestry, Jos Plateau State Nigeria

3Department of Microbiology, Faculty of Natural and Applied Sciences, Plateau State University, Bokkos, Plateau State, Nigeria

4Centre for Phage Biology and Therapeutics, Jos, Plateau State, Nigeria

*Correspondence to: olufunmilolaolorundare@gmail.com; Tel: +2348069697670

 

Abstract:

 Background: Typhoid fever, caused by antibiotic-resistant Salmonella enterica serovar Typhi (Salmonella Typhi), is a significant public health issue, especially in Nigeria, necessitating exploration of alternative treatment strategies such as the use of bacteriophages. Bacteriophages are viruses that specifically infect and replicate within bacteria and play important roles in medicine. The objective of this study is to isolate and characterize two lytic phages against S. Typhi, assess their stability under various environmental conditions and determine their potentials as biocontrol agents and alternatives to antibiotics for treatment of S. Typhi infections. Continue reading “Exploring lytic Salmonella phages as potential alternatives to antibiotics: Isolation, characterization, and stability assessment of Jerseyvirus Ijeoma and Apdecimavirus Ayanbimpe”

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Prevalence of β-lactamase-encoding genes in Salmonella Typhi isolates from patients attending secondary healthcare facilities in Benue south senatorial district, northcentral Nigeria

[1],[2],[3]Adikwu, P., *1Oche, D. A., 2Umeh, E. U., 2Ogbonna, I. O., 2Iheukwumere, C. C., [4]Obande, G. A., [5]Oyiwona, G. E., 2Adole, P. I., 1Agbo, A. A., 2Ochekpe, S. O., 3Okoh, M. E., and 3Soom, S. T.

[1] Département de Microbiologie, Faculté des Sciences, Université Fédérale des Sciences de la Santé d’Otukpo, État de Benue, Nigéria

[2] Département de Microbiologie, Université Fédérale d’Agriculture, Makurdi, État de Benue, Nigéria

[3] 3Département de Microbiologie, Université d’État de Benue Makurdi, État de Benue, Nigéria

[4] 4Département de Microbiologie, Université Fédérale, Lafia, État de Nasarawa, Nigéria

[5] Département de Technologie de Laboratoire Scientifique, École Polytechnique de l’État de Benue, Ugbokolo,

Abstract:

 Background: The emergence of multi-drug resistant (MDR) Salmonella Typhi poses a major challenge in the treatment of typhoid fever using commonly available antibiotics. However, in many rural and semi-urban communities of low- and middle-income countries (LMICs), routine surveillance for MDR S. Typhi is scarcely undertaken. The aim of this study is to determine the prevalence of β-lactamase genes in MDR S. Typhi isolated from patients in nine secondary healthcare facilities in Benue south senatorial district, northcentral Nigeria. Continue reading “Prevalence of β-lactamase-encoding genes in Salmonella Typhi isolates from patients attending secondary healthcare facilities in Benue south senatorial district, northcentral Nigeria”

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Antimicrobial susceptibility and plasmid profiles of Salmonella Typhi in Sagamu, southwest Nigeria

*1Ogunyemi, D. T., and 2Ogunyemi, A. O.

1Department of Pathology, Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria

2Department of Microbiology, Olabisi Onabanjo University, Ago-Iwoye, Nigeria

*Correspondence to: ogunyemidamilare@gmail.com; +2348140093814; ORCID: 0009-0005-3456-4036

 

Abstract:

 Background: Salmonella enterica serovar Typhi is the causative agent of typhoid fever, a major public health concern in Nigeria and other low-resource settings. The emergence of antimicrobial resistance (AMR), often plasmid-mediated, poses a serious challenge to treatment. Local surveillance data on resistance and plasmid carriage are critical for guiding effective interventions. This study investigated the antimicrobial susceptibility and plasmid profiles of clinical Salmonella Typhi isolates from stool samples in Sagamu, southwest Nigeria. Continue reading “Antimicrobial susceptibility and plasmid profiles of Salmonella Typhi in Sagamu, southwest Nigeria”