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Prevalence of mecA and vanA genes in nasal Staphylococcus aureus isolates from hospitalized patients in Babcock University Teaching Hospital, Ilishan-Remo, Nigeria

*¹Okunbor, H. N., ¹,²Otaigbe, I. I., ¹,²Oluwole, T. O., ¹,²Elikwu, C. J., and 3Bhola, A. K.

¹Department of Medical Microbiology, Babcock University Teaching Hospital, Ilishan-Remo, Ogun State, Nigeria

²Department of Medical Microbiology and Parasitology, Babcock University, Ilishan-Remo, Ogun State, Nigeria

³ISID-BMGF Research Capacity Building Mentor

*Correspondence to: okunborh@babcock.edu.ng; Tel: +2348059834262; ORCID: 0009-0001-2016-6310

Abstract:

Background: Antimicrobial resistance (AMR) among Staphylococcus aureus, particularly methicillin-resistant S. aureus (MRSA) and vancomycin-resistant S. aureus (VRSA), poses a major global public health challenge. Data on the molecular epidemiology of resistance genes in Nigeria remain limited. The objectives of this study are to determine the prevalence of mecA, vanA, and vanB genes among nasal S. aureus isolates, assess antimicrobial susceptibility profiles, and explore associations of prevalence with demographic and clinical characteristics of hospitalized patients in Babcock University Teaching Hospital (BUTH), Ilishan-Remo, Nigeria. Continue reading “Prevalence of mecA and vanA genes in nasal Staphylococcus aureus isolates from hospitalized patients in Babcock University Teaching Hospital, Ilishan-Remo, Nigeria”

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Emergence of clinical vanA-type vancomycin-resistant Staphylococcus aureus isolates in National Orthopaedic Hospital Dala, Kano, Nigeria

*[1],3Abdulrahim, U., [2]Oche, D. A., [3]Kachallah, M., 4Adeshina, G. O., and 4Olayinka, B. O.

 1Department of Medical Microbiology, School of Basic Medical Sciences,              Central South University, Hunan Province, China

2Department of Microbiology, Faculty of Science, Federal University of               Health Sciences Otukpo, Benue State, Nigeria

3Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, University of Maiduguri, Borno State, Nigeria                                                  4Department of Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria                       *Correspondence to: uabdulrahim@csu.edu.cn and uabdulrahim@unimaid.edu.ng

Abstract:  

Background: The increasing prevalence of multi drug resistance (MDR) in strains of Staphylococcus aureus is a major challenge in the selection of an appropriate therapeutic agents, especially in persistent orthopaedic infections. This study investigated the patterns of antimicrobial resistance and identified the genetic determinants of resistance in S. aureus isolates from orthopaedic patients. Continue reading “Emergence of clinical vanA-type vancomycin-resistant Staphylococcus aureus isolates in National Orthopaedic Hospital Dala, Kano, Nigeria”