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Spectrum of bacterial uropathogens and their antibiotic susceptibility among patients with chronic kidney disease in a tertiary hospital, northcentral Nigeria

1Abdullahi, A. J., 2Babaita, K. A., *2Ogunniyi, T. J., 3Oyedepo, D. S., and 1Akanbi II, A. A.

1Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical Sciences, University of Ilorin, Ilorin, Nigeria

2Department of Medical Microbiology and Parasitology, University of Ilorin Teaching Hospital, Ilorin, Nigeria

3Department of Nephrology, University of Ilorin Teaching Hospital, Ilorin, Nigeria

*Correspondence to: josephtolulopeogunniyi@gmail.com

Abstract:

Background: Chronic kidney disease (CKD) is increasingly recognized as a global public health problem. CKD patients are prone to comorbidities, such as diabetes mellitus, urinary tract infection (UTI), hypertension, immunesuppression, anaemia, malnutrition, inflammation, and vitamin deficiencies. However, UTI is known to be the most significant cause of morbidity and mortality in CKD patients. Therefore, this study aimed to identify the spectrum of uropathogenic bacteria in patients with CKD at the University of Ilorin Teaching Hospital (UITH), Ilorin, and determine their susceptibility to selected antibiotics.    Continue reading “Spectrum of bacterial uropathogens and their antibiotic susceptibility among patients with chronic kidney disease in a tertiary hospital, northcentral Nigeria”

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A survey on urinary tract infection associated with two most common uropathogenic bacteria

R.O. Okojie, V.O. Omorokpe

 

Abstract

The aim of this study was to determine the prevalence of urinary tract infection (UTI) caused by the uropathogens – Escherichia coli and Klebsiella pneumoniae among outpatients attending a hospital in Benin and the  antibiotic susceptibility pattern of both isolates. Mid-stream urine samples were collected from 96 patients, analysed microscopically and streaked on the surface of prepared plates of blood and MacConkey Agar. Isolates resulting from incubated plates were identified by standard microbiological techniques. Susceptibility testing was done using the disk diffusion  technique on Mueller Hinton Agar. The prevalence of UTI was 22.9%. It was significantly more prevalent in females (30.6%) than males (8.8%) (p < 0.05) and in age group 31 – 40 years (45.5%). Escherichia coli was the most commonly isolated and more prevalent (14.6%) followed by Klebsiella pneumoniae (5.2%). High level resistance (100%) to amoxycillin/clavulanic acid, ampicillin and ceftazidime was observed among the isolates. The active drugs against the bacteria were nitrofurantoin, ofloxacin and imipenem. Routine diagnostic procedure/screening is necessary to avoid complications.

Keywords: Infection, prevalence, resistance, uropathogens.

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