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Spectrum of bacterial uropathogens and their antibiotic susceptibility among patients with chronic kidney disease in a tertiary hospital, northcentral Nigeria

1Abdullahi, A. J., 2Babaita, K. A., *2Ogunniyi, T. J., 3Oyedepo, D. S., and 1Akanbi II, A. A.

1Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical Sciences, University of Ilorin, Ilorin, Nigeria

2Department of Medical Microbiology and Parasitology, University of Ilorin Teaching Hospital, Ilorin, Nigeria

3Department of Nephrology, University of Ilorin Teaching Hospital, Ilorin, Nigeria

*Correspondence to: josephtolulopeogunniyi@gmail.com

Abstract:

Background: Chronic kidney disease (CKD) is increasingly recognized as a global public health problem. CKD patients are prone to comorbidities, such as diabetes mellitus, urinary tract infection (UTI), hypertension, immunesuppression, anaemia, malnutrition, inflammation, and vitamin deficiencies. However, UTI is known to be the most significant cause of morbidity and mortality in CKD patients. Therefore, this study aimed to identify the spectrum of uropathogenic bacteria in patients with CKD at the University of Ilorin Teaching Hospital (UITH), Ilorin, and determine their susceptibility to selected antibiotics.    Continue reading “Spectrum of bacterial uropathogens and their antibiotic susceptibility among patients with chronic kidney disease in a tertiary hospital, northcentral Nigeria”

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Prevalence and identification of microbial contaminants of reusable plastic containers from informal food vending sites in Calabar, Nigeria

*[1]Usang, A., [2]Omeh, B. A., and [3]Ekuma, V. O.

1Faculty of Medical Laboratory Science, University of Calabar, PMB 1115, Calabar, Nigeria

2Department of Medical Laboratory Science, College of Health Technology, Calabar, Nigeria

3Department of Parasitology and Entomology, University of Calabar, Nigeria *Correspondence to: akedorusang2rue@gmail.com

 

Abstract

 Background: Reusable plastic containers are widely used in informal food vending sites in developing countries like Nigeria, posing potential risks for microbial contamination and foodborne illnesses. This study determined the prevalence and identify microbial contaminants in 350 reusable plastic containers sampled from selected sites (markets, schools, roadside sellers, hawkers, and motor parks) in Calabar, Nigeria. Continue reading “Prevalence and identification of microbial contaminants of reusable plastic containers from informal food vending sites in Calabar, Nigeria”

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Discovery of potential antiviral compounds against Dengue virus using virtual screening and physicochemical profiling from zinc database

1Ramdeen, S. J., 1Usoro, N., 1Giordano, K., 1Garza, P. E., 2Quadri, O., 3Esan, T. E., and *1Olanrewaju,A. A.

 1Texas State University, Medical Laboratory Science Program San Marcos, TX USA

2Northern Illinois University, Chemistry and Biochemistry Analytical Lab, Dekalb, IL USA

3Rosalind Franklin University of Medicine and Science, Chicago, IL USA

*Correspondence to: dep112@txstate.edu; Phone: +1 571-228-0537

Erratum to: Afr. J. Clin. Exper. Microbiol. 2026; 27 (2): 126-133. https://dx.doi.org/10.4314/ajcem.v27i2.1

A publication error in the name of author, Quadri, P., in the previously published version of this article has been appropriately corrected as Quadri, O., in this authors page. All information in the previously published article remained valid.

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Prevalence and predictors of hepatitis B screening among pregnant women attending antenatal clinics in three primary health centres in Abeokuta, Nigeria: A cross-sectional study

*Olatunji, O. A., Fowotade, A., and Omoruyi, E. C.

Department of Medical Microbiology, University College Hospital (UCH), Ibadan, Nigeria

*Correspondence to: aliu_my2004@yahoo.com

Corrigendum to: Afr. J. Clin. Exper. Microbiol. 2026; 27 (1): 46-53 https://dx.doi.org/10.4314/ajcem.v27i1.7

An error by the authors in a previously published version of this article with respect to arrangement of authors names, has been appropriately corrected in this authors page. All information in the previously published article remained valid.

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Discovery of potential antiviral compounds against Dengue virus using virtual screening and physicochemical profiling from zinc database

1Ramdeen, S. J., 1Usoro, N., 1Giordano, K., 1Garza, P. E., 2Quadri, O., 3Esan, T. E.,  and *1Olanrewaju,A. A.

1Texas State University, Medical Laboratory Science Program San Marcos, TX USA

2Northern Illinois University, Chemistry and Biochemistry Analytical Lab, Dekalb, IL USA

3Rosalind Franklin University of Medicine and Science, Chicago, IL USA *Correspondence to: dep112@txstate.edu; Phone: +1 571-228-0537

Abstract:

Background: Dengue, a mosquito-borne virus infection, reportedly affected over 7.6 million people in early 2024, subsequently leading to approximately 3000 deaths. Dengue is primarily spread by Aedes (A. aegypti and A. albopictus) mosquitoes. There is currently no clinically approved preventive vaccine against Dengue virus (DENV), and according to the Center for Disease Control (CDC), the only acceptable vaccine for DENV is Dengvaxia, which has efficacy and safety issues. This makes it unsuitable for use against DENV. Drug repurpose is an alternative approach for the discovery of novel therapeutics. Continue reading “Discovery of potential antiviral compounds against Dengue virus using virtual screening and physicochemical profiling from zinc database”

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Exploring lytic Salmonella phages as potential alternatives to antibiotics: Isolation, characterization, and stability assessment of Jerseyvirus Ijeoma and Apdecimavirus Ayanbimpe

*[1],[2]Olorundare, O. O., [3],4Nnadi, N. E., 1Nimzing, L., 1Ayanbimpe, G. M.

1Department of Medical Microbiology, Faculty of Basic Clinical Science, University of Jos, Plateau State, Nigeria

2Department of Pest Management Technology, Federal College of Forestry, Jos Plateau State Nigeria

3Department of Microbiology, Faculty of Natural and Applied Sciences, Plateau State University, Bokkos, Plateau State, Nigeria

4Centre for Phage Biology and Therapeutics, Jos, Plateau State, Nigeria

*Correspondence to: olufunmilolaolorundare@gmail.com; Tel: +2348069697670

 

Abstract:

 Background: Typhoid fever, caused by antibiotic-resistant Salmonella enterica serovar Typhi (Salmonella Typhi), is a significant public health issue, especially in Nigeria, necessitating exploration of alternative treatment strategies such as the use of bacteriophages. Bacteriophages are viruses that specifically infect and replicate within bacteria and play important roles in medicine. The objective of this study is to isolate and characterize two lytic phages against S. Typhi, assess their stability under various environmental conditions and determine their potentials as biocontrol agents and alternatives to antibiotics for treatment of S. Typhi infections. Continue reading “Exploring lytic Salmonella phages as potential alternatives to antibiotics: Isolation, characterization, and stability assessment of Jerseyvirus Ijeoma and Apdecimavirus Ayanbimpe”

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Rotavirus serotypes/genotypes distribution and their implications in children with diarrhoea admitted to the Charles de Gaulle University Paediatric Hospital, Ouagadougou, Burkina Faso

[1],[2]Tondé, I., [3],[4]Savadogo, H., 2,[5]Ky-Ba, A., 1Drabo, D. C., 6,7Tranchot-Diallo, J.,

1Tamboura, M., 1Kam, M., 1,2Sanou, M., 7,8Ouédraogo, A-S., 2,9Sanou, I., and 1,2Ouédraogo-Traoré, R.

1Centre Hospitalier Universitaire Pédiatrique Charles De Gaulle, Burkina Faso

2Université Joseph Ki-Zerbo, Burkina Faso

3Centre Hospitalier Universitaire Regional de Ouahigouya, Burkina Faso

4Université de Ouahigouya, Burkina Faso

5Centre Hospitalier Universitaire du District de Bogodogo, Burkina Faso

6Centre Muraz, Institut National de Santé Publique (INSP), Burkina Faso

7Université Nazi Boni, Burkina Faso

8Centre Hospitalier Universitaire Sanou-Sourô, Burkina Faso

9Centre Hospitalier Universitaire Tengandogo, Burkina Faso *Correspondence to: issa.tonde@ujkz.bf

Abstract:

Background: Diarrhoeal diseases are a source of public health problems in low-income countries such as Burkina Faso, where the aetiology of rotavirus plays an important role. This led to the introduction of surveillance since the introduction of the rotavirus vaccine. The aim of this study is to take stock of rotavirus diarrhoea since the introduction of the vaccine.     Continue reading “Rotavirus serotypes/genotypes distribution and their implications in children with diarrhoea admitted to the Charles de Gaulle University Paediatric Hospital, Ouagadougou, Burkina Faso”

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Comparative performance of Cobas 4800 and 5800 assays with Cobas 6800 assay for detecting/genotyping high-risk HPV in cervical samples: An interlaboratory evaluation in Maputo, Mozambique

*1,2Sineque, A.,  1Condo, T., 3Sebastião, J.,  3Nhambe, C., 4Manuel, M., 1Mabasso, A., 3Sidumo, Z., 5Ceffa, S., and 5,6Ciccacci, F.

1Department of Biological Sciences, Faculty of Science, Eduardo Mondlane University, Maputo, Mozambique

2Centre for Functional Ecology–One Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal

3DREAM Program, Community of Saint’Egidio, Maputo, Mozambique

4Laboratory of Mavalane General Hospital, Maputo, Mozambique

5DREAM Program, Community of Saint’Egidio, Roma, Italy

6University of Rome Tor Vergata, Department of Biomedicine and Prevention, Rome, Italy

*Correspondence to: sineque.alberto@uem.ac.mz; Tel: +258 826 459 243; ORCiD: https://orcid.org/0000–0003–2468–9925

 

Abstract:

 Background: High-risk (hr) human papillomaviruses (HPV) testing is immensely important in elucidating molecular epidemiology of HPV infections and has become an essential part of current clinical practice in the management of the precancerous lesions and cervical cancer risks. Evaluation of HPV testing systems suitable for large-scale organized cervical screening programs is required. Very little is known about the diagnostic performance of the Cobas assays in resource-limited settings, particularly in Mozambique. We evaluated the concordance of the Cobas 4800 and Cobas 5800 assays with the Cobas 6800 assay for detecting high-risk HPV genotypes in clinician-collected cervical samples. Continue reading “Comparative performance of Cobas 4800 and 5800 assays with Cobas 6800 assay for detecting/genotyping high-risk HPV in cervical samples: An interlaboratory evaluation in Maputo, Mozambique”

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Assessment of genetic diversity among environmental Cryptococcus species using RAPD analysis

*Coker, M. O., Thomas, B. T., Efuntoye, M. O., and Popoola, O. D.

Department of Microbiology, Olabisi Onabanjo University, Ago-Iwoye, Ogun State, Nigeria.

*Correspondence to: olawunmimercy707@gmail.com; Mobile: +2349054006625;

ORCID ID: https://orcid.org/0000–0003–0937–7755

 

Abstract:

 Background: Cryptococcus species, including C. neoformans and C. gattii, are environmental yeasts of clinical importance and major agents of cryptococcosis. Environmental reservoir represents the primary source of human and animal infections therefore, characterization of genetic diversity is essential for epidemiological surveillance and understanding the pool of genotypes from which pathogenic strains may arise. Continue reading “Assessment of genetic diversity among environmental Cryptococcus species using RAPD analysis”

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Profile of multidrug-resistant bacteria in neonatal nosocomial infections at the Brazzaville University Hospital, Congo

*[1],[2]Ontsira Ngoyi, E. N., 1,[3]Mieret, T.,2Moundzele, L., 1,[4]Ngakengy, N.,1Niabia, O. E., and 1,4Ekouya, G.    

1Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congo  2Bacteriology-Virology Laboratory, Brazzaville University Hospital, Congo           3National Public Health Laboratory, Brazzaville, Congo                               4Neonatology Department, Brazzaville University Hospital, Congo                     *Correspondence to: esther_muller20023@yahoo.fr

Abstract:

Background: Antibiotic resistance represents a major threat in neonatology, particularly in sub-Saharan Africa where local data remain limited. The present study aims to establish the profile of multidrug-resistant bacteria isolated from cases of neonatal nosocomial infections at the Brazzaville University Hospital, Congo.      Continue reading “Profile of multidrug-resistant bacteria in neonatal nosocomial infections at the Brazzaville University Hospital, Congo”