In vitro effect of some quinolone antibiotics on strains of Staphylococcus aureus isolated from a hospital environment

RK Obi, FC Nwanebu



A total of 30 different strains of Staphylococcus aureus were isolated from some selected wards of Madonna University Teaching Hospital (MUTH), Elele, Nigeria, using blood agar and nutrient agar. All the isolates were subjected to some selected quinolones (ciprofloxacin, pefloxacin, ofloxacin, norfloxcin and sparfloxacin) to determine their antibiotic susceptibility pattern using the disk diffusion method. Ofloxacin had the highest percentage
susceptibility of 93.3%, followed by ciprofloxacin with 73.3%; pefloxacin was next with 70%, sparfloxacin 63.3%, while norfloxacin recorded the lowest percentage of 50%. The minimum inhibitory concentration (MIC) of the quinolones to the isolates was also determined. The results show that all the tested quinolones had an MIC ranging from 2.5-10mg/ml.

KeywordsStaphylococcus aureus, quinolones, hospital environment

African Journal of Clinical and Experimental Microbiology Vol. 9 (3) 2008: pp. 142-146